SOX2 regulates P63 and stem/progenitor cell state in the corneal epithelium

This study demonstrates that SOX2 regulates and interacts with P63 and that both transcription factors control the stem/progenitor cell state. By contrast, downregulation of SOX2/P63 by miR‐450b induces cell differentiation. Given that congenita l point mutations in SOX2 or P63 were linked with multiple eye abnormities, a better understanding of this molecular network will shed light on disease mechanisms and may potentially be harnessed into novel therapeutic approaches to restore vision.© AlphaMed Press 2018

Source: Stem Cells - December 10, 2018 Category: Stem Cells Authors: Swarnabh Bhattacharya, Laura Serror, Eshkar Nir, Dalbir Dhiraj, Anna Altshuler, Maroun Khreish, Beatrice Tiosano, Peleg Hasson, Lia Panman, Chen Luxenburg, Daniel Aberdam, Ruby Shalom ‐Feuerstein Tags: Tissue ‐Specific Stem Cells Source Type: research