Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk

We describe cell type–specific chromosomal connectomes composed of schizophrenia risk variants and their distal targets, which altogether show enrichment for genes that regulate neuronal connectivity and chromatin remodeling, and evidence for coordinated transcriptional regulation and proteomic interaction of the participating genes. Developmentally regulated chromosomal conformation changes at schizophrenia-relevant sequences disproportionally occurred in neurons, highlighting the existence of cell type–specific disease risk vulnerabilities in spatial genome organization.

Source: ScienceNOW - December 13, 2018 Category: Science Authors: Rajarajan, P., Borrman, T., Liao, W., Schrode, N., Flaherty, E., Casino, C., Powell, S., Yashaswini, C., LaMarca, E. A., Kassim, B., Javidfar, B., Espeso-Gil, S., Li, A., Won, H., Geschwind, D. H., Ho, S.-M., MacDonald, M., Hoffman, G. E., Roussos, P., Zh Tags: Genetics, Neuroscience, Online Only special/r-articles Source Type: news