[The syndrome of inappropriate diuretic hormone secretion (SIADH) ending lethal during the use of paliperidon and lamotrigine].

We describe a 35-year-old woman who died due to lack of recognition of SIADH. The patient, who had a bipolar disorder and was for a long time on a paliperidone depot, developed complaints of nausea, vomiting and thirst after lamotrigine was prescribed. A few days after increasing the dose, she died; no evidence was found of suicide. The SIADH was probably triggered by the use of lamotrigine and paliperidone. Paying sufficient attention to the symptoms that may cause this syndrome, as well as their early recognition, could save lives. PMID: 30536299 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/30536299?dopt=Abstract

Source: Tijdschrift voor Psychiatrie - December 13, 2018 Category: Psychiatry Authors: Monden MAH, van der Vorst LP, Martens HJM, van der Wolk A Tags: Tijdschr Psychiatr Source Type: research