Association Between Serum Folate Level and Toxicity of Capecitabine During Treatment for Colorectal Cancer

AbstractBackground.Folate level was proposed to be a predictor for fluoropyrimidine‐related toxicity. We conducted a prospective study to determine the association between serum and red‐cell folate and capecitabine‐related toxicity in patients with colorectal cancers.Materials and Methods.Eligibility criteria included diagnosis of colorectal cancers; eligible patients who were scheduled to undergo capecitabine monotherapy or capecitabine‐oxaliplatin (CAPOX) for adjuvant or palliative purposes. Exclusion criteria included concomitant radiotherapy or chemotherapy other than capecitabine or CAPOX and creatinine clearance

Source: The Oncologist - December 13, 2018 Category: Cancer & Oncology Authors: Stephen L. Chan, Anthony W.H. Chan, Frankie Mo, Brigette B.Y. Ma, Kenneth C.W. Wong, Daisy Lam, Florence S.T. Mok, Anthony T.C. Chan, Tony Mok, K.C. Allen Chan Tags: Review, Breast Cancer Gastrointestinal Cancer Source Type: research