Cervical Extraneural Lymph Node Metastasis in a Patient with Medulloblastoma
Conclusions: This is an institution-based, detailed, and descriptive epidemiological study of patients with primary CNS tumors in Saudi Arabia. In contrast to other regional and international studies, the medulloblastomas in our institution are more frequent than pilocytic astrocytomas. Limitations to our study included the referral bias and histology-based methodology. PMID: 32256589 [PubMed]
Contributors : Saihua Huang ; Ping Xue ; Yufeng ZhouSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensWe characterized circulating exosomal miRNA profiles by miRNA-seq to identify those differentially expressed in children with MB relative to heathy controls
Conditions: Solid Tumors; Neuroblastoma; Rhabdomyosarcoma; Ewing Sarcoma; Hepatoblastoma; Medulloblastoma Interventions: Drug: VAL-413; Drug: Temozolomide Sponsor: Valent Technologies, Inc. Not yet recruiting
Embryonal tumors of the central nervous system (CNS) are rare, high-grade neoplasms predominantly affecting the pediatric population. Well-defined embryonal tumors include medulloblastoma, atypical teratoid/rhabdoid tumor, embryonal tumor with multilayered rosettes, C19MC-altered and embryonal tumor with multilayered rosettes, not otherwise specified, pineoblastoma, pituitary blastoma, CNS neuroblastoma, and ganglioneuroblastoma. Although their prognosis is nearly uniformly poor, the rapidly evolving understanding of their molecular biology contributes to diagnosis, prognosis, treatment, and clinical trial participation. K...
Conditions: Brain Tumor; Medulloblastoma; Brain Metastases Intervention: Drug: WP1066 Sponsors: Emory University; CURE Childhood Cancer, Inc.; Peach Bowl LegACy Fund Not yet recruiting
Dr. Matija Snuderl, neuropathologist and molecular pathologist at New York University Langone Health, was featured ina recent article appearing inNature (March 26, 2020, Vol 579, p S14-S16). The article, which addresses the use of artificial intelligence (AI) in cancer diagnostics, opens with Dr. Snuderl experiencing a moment that many of us neuropathologists have had wherein we hesitate before signing out a case because of a feeling that something might be just a bit different about a particular specimen. That feeling prompts us to do something else (run more ancillary testing, get a consult, sleep on it and ta...
(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) The causes of 40 percent of all cases of certain medulloblastoma - dangerous brain tumors affecting children - are hereditary. These are the findings of a recent genetic analysis carried out by scientists from the Hopp Children's Cancer Center (KiTZ), the European Molecular Biology Laboratory (EMBL) and numerous colleagues around the world, which have just been published in the scientific journal Nature.
(St. Jude Children's Research Hospital) Collaboration co-led by researchers at St. Jude Children's Research Hospital discovers a novel predisposition gene in pediatric medulloblastoma.
(European Molecular Biology Laboratory) The causes of 40% of all cases of certain medulloblastomas -- dangerous brain tumors affecting children -- are hereditary. These are the findings of a recent genetic analysis carried out by scientists from the European Molecular Biology Laboratory (EMBL) and numerous colleagues around the world. A genetic defect that occurs in 15% of these children plays a key role by destabilizing the production of proteins. The researchers suspect that protein metabolism defects could be a previously underestimated cause of other types of cancer.
(St. Jude Children's Research Hospital) Scientists at St. Jude Children's Research Hospital have identified a novel target for a type of pediatric brain tumor.