Structural Insights into the Mechanism of Dynamin Superfamily Proteins.

Structural Insights into the Mechanism of Dynamin Superfamily Proteins. Trends Cell Biol. 2018 Dec 05;: Authors: Jimah JR, Hinshaw JE Abstract Dynamin superfamily proteins (DSPs) mediate membrane fission and fusion necessary for endocytosis, organelle biogenesis and maintenance, as well as for bacterial cytokinesis. They also function in the innate immune response to pathogens and in organizing the cytoskeleton. In this review, we summarize the current understanding of the molecular mechanism of DSPs, with emphasis on the structural basis of function. Studies from the past decade on the structure and mechanism of DSPs enable comparative analysis of shared mechanisms and unique features of this protein family. PMID: 30527453 [PubMed - as supplied by publisher]
Source: Trends in Cell Biology - Category: Cytology Authors: Tags: Trends Cell Biol Source Type: research