Perioperative gabapentin and post cesarean pain control: a systematic review and meta-analysis of randomized controlled trials

Publication date: Available online 12 December 2018Source: European Journal of Obstetrics & Gynecology and Reproductive BiologyAuthor(s): Laura Felder, Gabriele Saccone, Sergio Scuotto, David T. Monks, Jose C.A.Carvalho, Fulvio Zullo, Vincenzo BerghellaAbstractCesarean delivery occurs in roughly one third of pregnancies. Effective postoperative pain control is a goal for patients and physicians. Limiting opioid use in this period is important as some percentage of opioid naïve individuals will develop persistent use. Gabapentin is a non-opioid medication that has been used perioperatively to improve postoperative pain and limit opioid requirements. The goal of this study is to determine the efficacy of perioperative gabapentin in improving post cesarean delivery pain control. The following data sources were searched from their inception through October 2018: MEDLINE, Ovid, ClinicalTrials.gov, Sciencedirect, and the Cochrane Library at the CENTRAL Register of Controlled Trials. A systematic review of the literature was performed to include all randomized trials examining the effect of perioperative gabapentin on post cesarean delivery pain control and other postoperative outcomes. The primary outcome was analgesic effect of gabapentin on post cesarean delivery pain, measured by visual analog scale (VAS; 0-100) or Numerical Rating Scale (NRS; 0-10) on movement 24 hours postoperative. These scores were directly compared by multiplying all NRS scores by a factor of 10. Meta-an...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research