Pertussis epidemiology in Tunisian infants and children and characterization of Bordetella pertussis isolates: results of a 9-year surveillance study, 2007 to 2016.

CONCLUSION: This study demonstrated that pertussis is still present as a cyclical disease in Tunisia, despite high primo-vaccination coverage with a pertussis whole-cell vaccine. The predominant genotype of Tunisian B. pertussis isolates is similar to isolates circulating in countries using the acellular vaccine. PMID: 30526740 [PubMed - as supplied by publisher]
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research

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This study established surface shaving in B. pertussis, confirmed key expression differences and identified unknown surface proteins which may be potential vaccine antigens. PMID: 31703933 [PubMed - as supplied by publisher]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
CONCLUSION: Anti-vaccine ideas were born with vaccines; they are abundantly spread through the Internet and social networks and can give a false impression of their basis in reality. It is time for positive action not merely a defensive approach. PMID: 31522949 [PubMed - as supplied by publisher]
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
Authors: Barkoff AM, He Q Abstract Although vaccination has been effective, Bordetella pertussis is increasingly causing epidemics, especially in industrialized countries using acellular vaccines (aPs). One factor behind the increased circulation is the molecular changes on the pathogen level. After pertussis vaccinations were introduced, changes in the fimbrial (Fim) serotype of the circulating strains was observed. When bacterial typing methods improved, further changes between the vaccine and circulating strains, especially among the common virulence genes including pertussis toxin (PT) and pertactin (PRN) were ...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
The objective was to analyse genomic sequences of isolates collected during the 2014 whooping cough epidemic in Tunisia, a country where whole-cell vaccines are used. Ten Tunisian isolates and four vaccine strains were sequenced and compared to 169 isolates from countries where acellular vaccines are used. Phylogenetic analysis showed that Tunisian isolates are diverse, demonstrating a multi-strain 2014 epidemic peak, and are intermixed with those circulating in other world regions, showing inter-country transmission. Consistently, Tunisian isolates have antigen variant composition observed in other world regions. No perta...
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research
Legislators trying to curb the numbers of unvaccinated children have been met with vigorous opposition from upset parents.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Vaccination and Immunization Children and Childhood Parenting Freedom of Religion Whooping Cough Medicine and Health Measles Law and Legislation Mumps Epidemics Advisory Committee on Immunization Practices Centers for Disease Control Source Type: news
Christina Hildebrand went down a rabbit hole and emerged at the statehouse in Sacramento. That’s how she describes it–going down a rabbit hole–and in her case it happened 14 years ago, when she was pregnant with her first child. In a world filled with chemicals and toxins, processed foods and GMOs, she decided her baby would be brought up as naturally and chemical-free as possible. It was when she was researching how best to achieve that goal that she bumped into vaccines. That was a bad time to begin thinking about such things. The fraudulent 1998 paper by British physician Andrew Wakefield ostensibly li...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized vaccines Source Type: news
Family quarrels are usually private things—unless of course, the family is famous. A public spat among boldface names broke out on May 8, when three members of the Kennedy clan published a piece on Politico declaring that Robert F. Kennedy, Jr.—son of Bobby Kennedy—has been “tragically wrong” in his years-long crusade against vaccines, a crusade that seems especially irresponsible now as the country suffers through its worst measles outbreak since 1994. Kennedy has become a hero of the anti-vax crowd with his persistent claims that vaccines contain deadly ingredients, particularly a mercury-ba...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized History onetime Source Type: news
In this study we have evaluated whether our OMVs vaccine is capable of overcoming the deficiencies of commercial vaccines in both controlling infections caused by PRN(-) isolate/strain and inducing memory immunity. We found that our OMVs-based formulation has a higher protective capacity against the PRN(-) bacteria than that induced with a commercial aP vaccine. We found that CD4 T cells with a tissue-resident memory (TRM) cell phenotype (CD44+CD62LlowCD69+ and/or CD103+) accumulated in the lungs of mice after the second OMVs vaccine immunization. CD4 TRM cells were also detected in mice immunized with wP vaccine, but not ...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
In the midst of measles and flu epidemics, we are also seeing pertussis (whooping cough) come back. Anti-vaccination proponents have been the source of many outbreaks to date.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news
Decades of peer reviewed evidence demonstrate that: 1)Bordetellapertussisand pertussis toxin are potent adjuvants, inducing asthma and allergic sensitization in animal models of human disease, 2)Bordetella pertussisoften colonizes the human nasopharynx, and is well documented in highly pertussis-vaccinated populations and 3) in children, a history of whooping cough increases the risk of asthma and allergic sensitization disease. We build on these observations with six case studies and offer a pertussis-based explanation for the rapid rise in allergic disease in former East Germany following the fall of the Berlin Wall; the...
Source: Medical Hypotheses - Category: Biomedical Science Authors: Source Type: research
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