Adhesion and biofilm formation by Staphylococcus aureus clinical isolates under conditions relevant to the host: relationship with macrolide resistance and clonal lineages.

CONCLUSIONS: S. aureus biofilm formation appears to be more efficient in ESSA than ERSA, associated with specific S. aureus lineages, mainly CC8 and CC15, and affected by atmosphere. Further studies investigating the relationship between antibiotic resistance and biofilm formation could prove useful in the development of new strategies for the management of S. aureus infections. PMID: 30540247 [PubMed - as supplied by publisher]
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research

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This study underscores the capacity of human DC to discriminate between live and inactivated S. aureus and, further, indicates that DC may represent a valuable experimental setting to test different inactivation methods with regard to the retention of S. aureus immunoregulatory properties. These and further insights may be useful for the development of novel therapeutic and prophylactic anti-S. aureus vaccine strategies.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
ConclusionEthyl acetate &Water extracts have represented potent activity against Salmonella typhi, Escherichia coli, &Staphylococcus aureus bacteria as well, provided cytotoxicity against tested cancer cell lines. These results can be explored to identify individual phyto-molecules from the extracts for anticancer &antimicrobial potentials to identify new phytomedicines.
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
Series Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThis SuperSeries is composed of the SubSeries listed below.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Contributors : Tiffany Crawford Scharschmidt ; Johnathon LeechSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRNA sequencing of whole skin from neonatal mice colonized with Staphlyococcus epidermidis versus Staphylococcus aureus
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Contributors : Tiffany Crawford Scharschmidt ; Johnathon LeechSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRNA sequencing of Tregs from skin of neonatal mice colonized with Staphlyococcus epidermidis versus Staphylococcus aureus
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Contributors : Liang Chunguang ; Rios-Miguel Ana ; Jarick Marcel ; Priya Neurgaonkar ; Patrice Francois ; Jacques Schrenzel ; Knut Ohlsen ; Dandekar ThomasSeries Type : Expression profiling by arrayOrganism : Staphylococcus aureus ; Staphylococcus aureus subsp. aureus str. NewmanDifferent transcriptome, metabolome, and phosphoproteome studies have already indicated a regulatory role of Ser/Thr phosphorylation in the central metabolism of S. aureus. However, it remains still unknown how this exactly tunes its metabolism. For that reason, Extreme Pathway Analysis was used to understand metabolic flux regulation by Ser/Thr ph...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Staphylococcus aureus Staphylococcus aureus subsp. aureus str. Newman Source Type: research
Two new flavones, 8,4 ′-dimethoxy-6-(2-oxopropyl)-flavone (1) and 8,4 ′-dimethoxy-6-(3-hydroxypropyl)- flavone (2), were isolated from the seeds of Arctium lappa. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds1 and2 were evaluated for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity. The results showed that compounds1 and2 exhibited weak active with diameter of inhibition zone (IZD) 10.8 ± 1.0 and 9.3 ± 0.8 mm, respectively. Compounds1 and2 were also tested for antioxidant activity, and they show good an...
Source: Chemistry of Natural Compounds - Category: Chemistry Source Type: research
Possible mechanisms of the antimicrobial effects of polypeptide‑enriched Gastrodia elata Blume extracts. Mol Med Rep. 2019 Sep 25;: Authors: Kong F, Cai X, Zhai S, Wang R, Zheng X, Ma Y, Bi H, Wang D Abstract The present study aimed to evaluate the antimicrobial activity and the possible mechanisms of activity of polypeptide‑enriched Gastrodia elata extracts (GEP) against the gram‑negative bacteria Escherichia coli and Pseudomonas aeruginosa, the gram‑positive bacterium Staphylococcus aureus and the fungus Candida albicans. The antimicrobial activity of GEP was first confirmed by determining th...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
ConclusionAccording to this study MDR efflux pumps not only cause high-level resistance but also it considerably associated with over-expression of these genes. Due to the selective pressure on MRSA isolate, the enormous diversity of plasmid-encoded genes had been recorded in different regions, owing to the various numbers and types of isolates in each study or types of disinfectants for general use.
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Publication date: Available online 6 November 2019Source: Microbial PathogenesisAuthor(s): Marcos Guilherme da Cunha, Janaina de Cássia Orlandi Sardi, Irlan Almeida Freires, Marcelo Franchin, Pedro Luiz RosalenAbstractThe discovery of new drug candidates, especially from natural products, remains a promising approach to overcome the alarmingly high microbial resistance rates. A major 4-phenyl coumarin named cinnamoyloxy-mammeisin (CNM) isolated from stingless bee geopropolis showed interesting biological properties; however, its antimicrobial activity against Staphylococcus aureus has never been investigated. In ord...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
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