Simultaneous optimization of isocenter locations and sector duration in radiosurgery.

Simultaneous optimization of isocenter locations and sector duration in radiosurgery.
Phys Med Biol. 2018 Dec 11;:
Authors: Cevik M, Aleman DM, Lee Y, Berdyshev A, Nordstrom H, Riad S, Sahgal A, Ruschin M
Abstract
Stereotactic radiosurgery is an effective technique to treat brain tumors for which several inverse planning methods may be appropriate. We propose an integer programming model to simultaneous sector duration and isocenter optimization (SDIO) problem for Leksell Gamma Knife{\textregistered} Icon{\texttrademark} (Elekta, Stockholm, Sweden) to tractably incorporate treatment time. We devise a Benders decomposition scheme to solve the SDIO problem to optimality. The performances of our approaches are assessed using anonymized data from eight previously treated cases, and obtained treatment plans are compared against each other and against the clinical plans. The plans generated by our SDIO model all meet or exceed clinical guidelines while demonstrating high conformity.&#13.
PMID: 30537699 [PubMed - as supplied by publisher]

Source: Physics in Medicine and Biology - December 11, 2018 Category: Physics Authors: Cevik M, Aleman DM, Lee Y, Berdyshev A, Nordstrom H, Riad S, Sahgal A, Ruschin M Tags: Phys Med Biol Source Type: research