Diagnostic and therapeutic approaches in oral cavity granulomas based on new data concerning their origin and pathogenesis.

Diagnostic and therapeutic approaches in oral cavity granulomas based on new data concerning their origin and pathogenesis. Rom J Morphol Embryol. 2018;59(3):679-690 Authors: Boşca AB, Şovrea AS, Miclăuş V, Ruxanda F, Mihu CM, Melincovici CS, Constantin AM, Petrescu BN, Câmpian RS, Pârvu AE, Ilea A Abstract Giant cell granulomas in the oral cavity are reactive hyperplastic lesions that arise either peripherally in the mucoperiosteum or centrally in the bone. The peripheral giant cell granuloma (PGCG) is a benign lesion induced by local chronic irritation. It may develop at any age, and tends to be more frequent in females. Central giant cell granuloma (CGCG) is a reactive lesion of unknown etiology. It commonly occurs in children and young adults. It is also predominant in females and frequently located in the anterior part of the mandible. Histologically, PGCG and CGCG have similar features. The lesions are non-encapsulated proliferations of oval and spindle-shaped mononuclear cells (MCs) and multiple multinucleated giant cells (MGCs) in a vascular supporting stromal tissue, associated with foci of hemorrhage. Despite the similar microscopic features, PGCG and CGCG have different clinical behavior. PGCG is usually reduced in size and asymptomatic. It grows locally, as an exophytic lesion on the alveolar mucosa, but may become slightly infiltrative in the underlying periosteum and bone. After complete excision and curettage, it...
Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research