Non-duplex G-Quadruplex Structures Emerge as Mediators of Epigenetic Modifications.

Non-duplex G-Quadruplex Structures Emerge as Mediators of Epigenetic Modifications.
Trends Genet. 2018 Dec 04;:
Authors: Mukherjee AK, Sharma S, Chowdhury S
Abstract
The role of non-duplex DNA, the guanine-quadruplex structure in particular, is becoming widely appreciated. Increasing evidence in the last decade implicates quadruplexes in important processes such as transcription and replication. Interestingly, more recent work suggests roles for quadruplexes, in association with quadruplex-interacting proteins, in epigenetics through both DNA and histone modifications. Here, we review the effect of the quadruplex structure on post-replication epigenetic memory and quadruplex-induced promoter DNA/histone modifications. Furthermore, we highlight the epigenetic state of the telomerase promoter where quadruplexes could play a key regulatory role. Finally, we discuss the possibility that DNA structures such as quadruplexes, within a largely duplex DNA background, could act as molecular anchors for locally induced epigenetic modifications.
PMID: 30527765 [PubMed - as supplied by publisher]

Source: Trends in Genetics : TIG - December 4, 2018 Category: Genetics & Stem Cells Authors: Mukherjee AK, Sharma S, Chowdhury S Tags: Trends Genet Source Type: research