Stemness marker ALDH1A1 promotes tumor angiogenesis via retinoic acid/HIF-1 α/VEGF signalling in MCF-7 breast cancer cells

Aldehyde dehydrogenase 1A1 (ALDH1A1), a member of aldehyde dehydrogenase family, is a marker of stemness in breast cancer. During tumor progression cancer stem cells (CSCs) have been reported to secrete angiog...

Source: Journal of Experimental and Clinical Cancer Research - December 12, 2018 Category: Cancer & Oncology Authors: Valerio Ciccone, Erika Terzuoli, Sandra Donnini, Antonio Giachetti, Lucia Morbidelli and Marina Ziche Tags: Research Source Type: research