Aspartate aminotransferase to platelet ratio index (APRI) for differentiation of primary and secondary infection by dengue virus

CONCLUSION: APRI seems to be a powerful tool for early identification of DENV secondary infection cases in health centers.RESUMO INTRODU ÇÃO: A infecção pelo vírus da dengue (DENV) é considerada um grande problema de saúde pública nos países tropicais. A indisponibilidade de testes sorológicos em centros de saúde pública pode afetar negativamente o prognóstico do paciente. OBJETIVO: Este estudo teve como objetivo avalia r a precisão do volume médio de plaquetas (MPV) e o índice da relação de aspartato aminotransferase (AST) sobre plaquetas (APRI) como marcadores laboratoriais de infecção por DENV, que poderiam ser utilizados para diferenciar infecções primárias e secundárias. MÉTODOS: Foram avaliados o s resultados laboratoriais de 503 pacientes com teste rápido positivo para infecção por DENV. RESULTADOS: Foram observadas trombocitopenia grave e disfunção hepática em pacientes com infecção secundária heterogênea por DENV. Nossos dados sugerem que o APRI foi capaz de distinguir os pacie ntes com infecção primária e secundária (p = 0, 006), com relevante sensibilidade (75%) e especificidade (76%) e corte de 1, 06. Um total de 80 de 105 (76%) pacientes com infecção primária por DENV tinha A...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - Category: Pathology Source Type: research

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Source: Blood - Category: Hematology Authors: Tags: Free Research Articles COMMENTS Source Type: research
Dengue virus (DENV) is the most prevalent vector-borne viral pathogen, infecting millions of patients annually. Thrombocytopenia, a reduction in circulating platelet counts, is the most consistent sign of DENV-induced disease, independent of disease severity. However, the mechanisms leading to DENV-induced thrombocytopenia are unknown. Here, we show that thrombocytopenia is caused by serotonin derived from mast cells (MCs), which are immune cells that are present in the perivascular space and are a major peripheral source of serotonin. We show that during DENV infection, MCs release serotonin, which prompts platelet activa...
Source: Blood - Category: Hematology Authors: Tags: Thrombocytopenia, Phagocytes, Granulocytes, and Myelopoiesis, Platelets and Thrombopoiesis Source Type: research
Authors: Ray A, Mohta S, Soneja M, Jadon R, Wig N, Sood R Abstract Acute febrile illness (AFI) is one of the commonest indications for hospitalization and can present with varying severity including single or multiple organ dysfunction syndrome (MODS). During monsoon season, there is a spurt of AFI often caused by vector borne diseases leading to substantial morbidity and mortality. Our aim was to determine distribution of etiological causes, differential organ involvement and predictors of mortality in critically ill patients with AFI. It was a hospital based observational study which included patients with AFI wi...
Source: Drug Discoveries and Therapeutics - Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research
ConclusionsThis case report highlights the rare occurrence of Miller Fisher syndrome during the acute phase of dengue fever. Neurological manifestations may occur as a consequence of direct neurotropism of dengue virus.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
This study was aimed to compare the clinical profile and outcome in DF patients with or without skin involvement. Methods: This study included all the patients with DF from the acute febrile illness database of a tertiary care health centre in south India. These patients were further subgrouped into SP and SN (skin involvement positive and negative) based on the presence and absence of skin rash. Differences in clinical presentation, laboratory parameters, disease course, morbidity and outcome among patients with DF with or without skin rash were recorded and analysed statistically. Results: In total 387 patients (...
Source: Journal of Vector Borne Diseases - Category: Infectious Diseases Tags: J Vector Borne Dis Source Type: research
Publication date: May 2019Source: The Lancet Global Health, Volume 7, Issue 5Author(s): Vasin Vasikasin, Thanawith Rojdumrongrattana, Worayon Chuerboonchai, Thanawhan Siriwiwattana, Wittaya Thongtaeparak, Suchada Niyasom, Nawarat Lertliewtrakool, Sitawee Jitsiri, Dhitiwat ChangpradubSummaryBackgroundDengue is a common cause of acute liver failure in tropical countries. Paracetamol is the recommended antipyretic for dengue. Related observational studies in dengue have suggested that excessive paracetamol intake is related to hepatic injury. We aimed to evaluate whether standard dose paracetamol as an antipyretic in dengue i...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
Rajendra Kumar Pandey, Rohit Kumar Jain, Syed Zammeer HussainAnnals of Indian Academy of Neurology 2019 22(2):240-241 Pharyngeal-cervical-brachial (PCB) variant is a rare localized variant of Guillain–Barré syndrome that presents with a rapidly progressive oropharyngeal and cervicopharyngeal weakness associated with areflexia in the upper limb. Here, we are describing a case of a 20-year-old female who had a preceding history of fever with thrombocytopenia that was found to be dengue ELISA positive. This was followed by rapidly progressive weakness of cervical, bulbar, and bilateral facial muscles along with ar...
Source: Annals of Indian Academy of Neurology - Category: Neurology Authors: Source Type: research
ConclusionsIncreased incidence of dengue encephalopathy in the recent years, in the absence of single sensitive test and with variable cerebrospinal fluid and magnetic resonance imaging brain features and associated high morbidity and mortality, poses a huge problem for clinicians. This study may be helpful in focusing on early diagnosis and aggressive initial management that can influence the final outcome.
Source: Current Medicine Research and Practice - Category: General Medicine Source Type: research
Publication date: Available online 27 March 2019Source: Antiviral ResearchAuthor(s): Gopinathan Pillai Sreekanth, Jutatip Panaampon, Aroonroong Suttitheptumrong, Aporn Chuncharunee, Jintana Bootkunha, Pa-thai Yenchitsomanus, Thawornchai LimjindapornAbstractLiver injury is one of the hallmark features of severe dengue virus (DENV) infection since DENV can replicate in the liver and induce hepatocytes to undergo apoptosis. N-acetyl cysteine (NAC), which is a clinically-used drug for treating acetaminophen toxicity, was found to benefit patients with DENV-induced liver injury; however, its mechanism of action remains unclear....
Source: Antiviral Therapy - Category: Virology Source Type: research
Abstract Zoonoses such as Brucella, Mycobacterium bovis, Campylobacter, Salmonella, Escherichia coli, Listeria, etc. are spread by ingestion of contaminated unpasteurised milk products (from infected cattle) and result in infectious outbreaks, hospitalisations and mortality. In Southeast Asian countries, raw goat's milk is sometimes used for dengue infection-associated thrombocytopenia; however, evidence to support this sociocultural practice is lacking. A peak incidence of brucellosis cases may occur after a dengue season in communities where this practice is prevalent. PMID: 30895885 [PubMed - as supplied by publisher]
Source: Tropical Doctor - Category: Tropical Medicine Authors: Tags: Trop Doct Source Type: research
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