Imaging in the diagnosis of progressive supranuclear palsy

Source: Journal of Neurology - Category: Neurology Source Type: research

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Development of Specific Fluorogenic Substrates for Human β-N-Acetyl-D-hexosaminidase A for Cell-Based Assays. Chem Pharm Bull (Tokyo). 2020;68(6):526-533 Authors: Miura K, Aoyama Y, Natsu Y, Koyama R, Hirano T, Nishio T, Hakamata W Abstract Inhibitors of human β-N-acetyl-D-hexosaminidase (hHEX) A and human O-GlcNAcase (hOGA) reportedly play roles in multiple diseases, suggesting their potential for pharmacological chaperone (PC) therapy of Sandhoff disease (SD) and Tay-Sachs disease (TSD), as lysosomal storage diseases, and Alzheimer's disease and progressive supranuclear palsy, respectively...
Source: Chemical and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Chem Pharm Bull (Tokyo) Source Type: research
Tauopathies are a category of neurodegenerative diseases defined by the abnormal accumulation of misfolded tau protein aggregates (often in the form of amyloid filaments) within the brain. Tau proteins exist in six isoforms, three of which contain three microtubule binding regions (3R), and the remainder contain four microtubule binding regions (4R). Tauopathies are characterized, in part, based on the ratio of 3R/4R misfolded tau proteins that make up the aggregates. This technology enables rapid, ultrasensitive and economical differentiation of self-propagating tau aggregates associated with tauopathies in crude biospeci...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research
Conclusions: These results suggest that attention to specific depressive symptom profile can improve diagnostic sensitivity and can be used to provide more individualized patient care.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Progressive supranuclear palsy (PSP) is a complex clinicopathologic disease with no current cure or disease modulating therapies that can only be definitively confirmed at autopsy. Growing understanding of the phenotypic diversity of PSP has led to expanded clinical criteria and new insights into etiopathogenesis that coupled with improved in vivo biomarkers makes increased access to current clinical trials possible. Current standard-of-care treatment of PSP is multidisciplinary, supportive and symptomatic, and several trials of potentially disease modulating agents have already been completed with disappointing results.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research
Methylation of mitochondrial tRNAs (mt-tRNA) at the 9th position ( “p9 site”) is known to impact translational efficiency and downstream mitochondrial function; however, direct assessment of mt-RNA methylation ...
Source: BMC Medical Genomics - Category: Genetics & Stem Cells Authors: Tags: Research article Source Type: research
598Objectives: Progressive supranuclear palsy (PSP) is a neurodegenerative disorder associated with the accumulation of the tau 4R isoform in the microtubule-binding domain, predominantly, in the substantia nigra (ST), subthalamic nucleus (STN), and globus pallidum. The evidence supports an ongoing reorganization of the structural and functional connectivities in PSP that might be influenced by tau pathology. We aimed to assess the network properties derived from graph theoretical analysis of the functional and structural connectivities along the deep gray matter pathways and their relation to tau burden. Methods: Ten PSP ...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Multimodal Neuroimaging Source Type: research
Kuo-Wei Lee, Ching-Fang Chien, Meng-Ni Wu, Chiou-Lian Lai, Li-Min LiouNeurology India 2020 68(2):481-482 In order to make a correct diagnosis of idiopathic Parkinson's disease (PD), it is essential to exclude atypical parkinsonian features, such as early dementia, fall, and autonomic dysfunction. Rheumatoid arthritis (RA), which is a systemic inflammatory disorder, although most patients present in a polyarticular manner. Still some may also present with extra-articular involvement including skin, lung, heart, and the central or peripheral nervous systems. A possible pathogenetic link between RA and PD are proposed. H...
Source: Neurology India - Category: Neurology Authors: Source Type: research
342Objectives: Crossed cerebellar diaschisis (CCD) is a common incidental finding on 18F-FDG brain PET studies. This phenomenon has been commonly described in patients with stroke (1-7), but only few case reports or case series have described it in patients with neurodegenerative diseases (8-10). We assessed prevalence of CCD in a large cohort of patients with neurodegenerative diseases and investigated the relationship between CCD and cortical asymmetries of glucose metabolism, amyloid deposition (11C -PIB) and Tau burden (18F-Flortaucipir (FTP)). Methods: We included 76 healthy controls and 197 patients who underwent 18F...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Neurodegenerative Diseases Source Type: research
Conclusions: These preliminary results indicate a potential of [18F]PI-2620 tau PET to improve the imaging-based PSP diagnosis which seems to be able to provide information independent of the severity of the clinical phenotype. More research in this regard on larger sample sizes and also concerning the known visual PSP signs in MRI/our currently developed visual PSP [18F]PI-2620 tau PET scoring system is, thus, justified.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Neurology & amp; Psychiatry (Poster Session) Source Type: research
In this study, we aimed to investigate an analogous spatial covariance pattern exist in patients with DLB and how it characterize the boundary issues between DLB and PD. Methods: In this study, we prospectively recruited 20 patients with DLB and 20 age/gender matched healthy control subjects to perform FDG PET imaging. 33 patients with PD and 33 age/gender matched healthy control subjects were also enrolled (Scans from these subjects were originally used to identify the PDRP biomarker in Chinese population). DLB-related pattern(DLBRP)was identified in the DLB patients and corresponding control subjects by an automated netw...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Neurology & amp; Psychiatry (Poster Session) Source Type: research
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