On mechanisms of colicin import: the outer membrane quandary

Discussion of channel-forming colicins focuses mainly on colicin E1 for which BtuB is receptor and the OM TolC protein the proposed translocator. The ability of TolC, part of a multidrug efflux pump, for which there is no precedent for an import function, to provide a trans-periplasmic import pathway for colicin E1, is questioned on the basis of an unfavorable hairpin conformation of colicin N-terminal peptides inserted into TolC.

http://www.biochemj.org/cgi/content/short/475/23/3903?rss=1

Source: Biochemical Journal - December 12, 2018 Category: Biochemistry Authors: Cramer, W. A., Sharma, O., Zakharov, S. D. Tags: Review Articles Source Type: research