Implementation of the Pandemic Influenza Preparedness (PIP) Framework in the Eastern Mediterranean Region: July 2014-August 2016

Source: World Health Organization, Regional Office for the Eastern Mediterranean. Published: 2/2018. This 46-page document reports on the Pandemic Influenza Preparedness (PIP) activities in the Eastern Mediterranean Region and the seven member countries that are recipients of grants under the 2013 −2016 PIP Partnership Contribution Implementation Plan. During 2014−2016, the countries have shown progress in putting in place both hard and soft infrastructure and in building systems that address local needs and could be sustained over time for influenza surveillance and pandemic preparednes s. (PDF)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - Category: International Medicine & Public Health Source Type: news

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Conclusions: The clinical features and outcomes of pandemic (H1N1) 2009 influenza and current circulating seasonal influenza A strains were comparable in hospitalised patients. However, since both seasonal and pandemic influenza can lead to significant morbidity and mortality, the impact of pre-existing seasonal influenza should not be underestimated during the pandemic period. PMID: 31304711 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
After the initial identification of the H1N1 pandemic influenza strain in Mexico in April 2009 and its subsequent global spread, several monovalent influenza vaccines were developed as part of the pandemic response. Three of these vaccines, Pandemrix, Arepanrix and Focetria were adjuvanted. One of these, the AS03-adjuvanted Pandemrix vaccine, was primarily used in Europe. Following widespread Pandemrix vaccine administration in Scandinavia, an increased risk of narcolepsy was noted in observational studies. Subsequently, this increased risk was also reported in other European countries as well. In contrast, studies from Ca...
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Vaccine Reports Source Type: research
Contributors : R E Drury ; D O'Connor ; A PollardSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensTo describe vaccine associated changes in the expression of microRNAs 21 days after vaccination in children receiving one of two pandemic influenza (H1N1) vaccines.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens Source Type: research
The highly pathogenic H5N1 avian influenza virus (HPAIV) was first identified in China in 1996 [A/goose/Guangdong/1/1996 (Gs/GD)] and infected the human population in Hong Kong in 1997, with 18 recorded cases resulting in six deaths.1, 2 Since 2003, Gs/GD lineage H5N1 HPAIV infection in humans has been reported in 16 countries, with 860 laboratory-confirmed cases and 454 deaths as of 2018.3 Although human-to-human transmission has not been documented, H5N1 HPAIV has the potential to cause an influenza pandemic.
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research
Abstract Baloxavir showed broad-spectrum in vitro replication inhibition of 4 types of influenza viruses (90% effective concentration range 1.2-98.3 nmol/L); susceptibility pattern was influenza A ˃ B ˃ C ˃ D. This drug also inhibited influenza A viruses of avian and swine origin, including viruses that have pandemic potential and those resistant to neuraminidase inhibitors. PMID: 31287050 [PubMed - as supplied by publisher]
Source: Emerging Infectious Diseases - Category: Infectious Diseases Authors: Tags: Emerg Infect Dis Source Type: research
Publication date: Available online 9 July 2019Source: Antiviral ResearchAuthor(s): Mingxin Li, Li Chen, Qingguang Wang, Mengchan Hao, Xiaoqing zhang, Linlin Liu, Xiao Yu, Chunpeng Yang, Junqiang Xu, Jianjun Chen, Rui GongAbstractSubtype H7 avian influenza viruses have been found to be associated with human infection and represent a risk for global public health. In 2013, the emergence of H7N9 virus in human beings and persistent human infection in China raised the most serious pandemic threat. Here we identified a human monoclonal antibody, P52E03, targeting the hemagglutinin (HA) of subtype H7 influenza viruses (H7 antige...
Source: Antiviral Therapy - Category: Virology Source Type: research
Abstract Avian influenza virus (AIV) is an extraordinarily diverse pathogen that causes significant morbidity in domesticated poultry populations and threatens human life with looming pandemic potential. Controlling avian influenza in susceptible populations requires highly effective, economical and broadly reactive vaccines. Several AIV vaccines have proven insufficient despite their wide use, and better technologies are needed to improve their immunogenicity and broaden effectiveness. Previously, we developed a "mosaic" H5 subtype hemagglutinin (HA) AIV vaccine and demonstrated its broad protection aga...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Abstract Subtype H7 avian influenza viruses have been found to be associated with human infection and represent a risk for global public health. In 2013, the emergence of H7N9 virus in human beings and persistent human infection in China raised the most serious pandemic threat. Here we identified a human monoclonal antibody, P52E03, targeting the hemagglutinin (HA) of subtype H7 influenza viruses (H7 antigen), from a convalescent patient infected with H7N9 in 2017. P52E03 showed in vitro hemagglutination inhibiting (HI) and neutralizing activity against subtype H7 viruses belonging to both North American and Euras...
Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
r Iqbal H9N2 avian influenza viruses have become globally widespread in poultry over the last two decades and represent a genuine threat both to the global poultry industry but also humans through their high rates of zoonotic infection and pandemic potential. H9N2 viruses are generally hyperendemic in affected countries and have been found in poultry in many new regions in recent years. In this review, we examine the current global spread of H9N2 avian influenza viruses as well as their host range, tropism, transmission routes and the risk posed by these viruses to human health.
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
School-closure policies are considered one of the most promising nonpharmaceutical interventions for mitigating seasonal and pandemic influenza. However, their effectiveness is still debated, primarily due to the lack of empirical evidence about the behavior of the population during the implementation of the policy. Over the course of the 2015 to...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: PNAS Plus Source Type: research
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