Non-alcoholic fatty liver disease – A global public health perspective

As the epidemics of obesity and type 2 diabetes mellitus increase worldwide, the prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing proportionately. The subtype of NAFLD which can be characterised as non-alcoholic steatohepatitis (NASH) is a potentially progressive liver disease that can lead to cirrhosis, hepatocellular carcinoma, liver transplantation, and death. NAFLD is also associated with extrahepatic manifestations such as chronic kidney disease, cardiovascular disease and sleep apnoea.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Public Health Source Type: research

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ConclusionsThese findings indicate that the neural effects of AUD vary according to severity. Our results emphasize the utility of resting state fMRI as a neuroimaging biomarker for quantitative clinical evaluation of AUD.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
ConclusionsA clinically relevant model of PTA of venous stenosis in mice was created. PTA-treated vessels had increased lumen vessel area and WSS. The alterations in tissue markers of vascular remodeling, tissue hypoxia, proliferation, and cell death may be implications for future design of drug and device development.
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
ConclusionsThe results pointed out that the high expression of miR-106b-5p serves as an independent factor for predicting the worse prognosis of RCC patients.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Publication date: Available online 28 February 2019Source: Journal of Minimally Invasive GynecologyAuthor(s): Sadikah Behbehani, Tiffany Pham, Katie Kunze, Megan Wasson, Johnny YiABSTRACTStudy ObjectiveTo determine the incidence of a successful in-office voiding trial after minimally invasive hysterectomy.DesignA retrospective cohort study.SettingA tertiary care academic center.PatientsAll patients undergoing minimally invasive hysterectomies (vaginal, laparoscopic, or robotic) from January 2013 to July 2018 who have an unsuccessful voiding trial in the postoperative unit.InterventionsA voiding trial.Measurements and Main ...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
In conclusion, clinical presentation at time of diagnosis of brain metastases consistently includes neurologic signs and symptoms with persistent headache being the most common. Endometrial cancer patients that present with new neurologic complaints or exam findings should be evaluated for brain metastases.
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
We describe a case of an 80-year-old woman with ovarian metastasis of MCC six years after excision of a cutaneous MCC on the cheek.DiscussionTo our knowledge only three cases with ovarian metastasis of MCC have been described so far. Our case is the second with distant metastasis to the ovary spreading from a primary tumor in the skin of the head, in the other two cases the primary tumor was in the inguinal skin.ConculsionMCC is a highly aggressive cutaneous and mucosal malignancy with frequent recurrence, lymph node and distant metastases. There is no clear consensus how to treat metastatic disease.
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
Conclusions: BMI and WC may predict incident hypertension better than skinfold thickness, WHR, and WHTR in the Chinese population.Ann Nutr Metab 2019;74:215 –223
Source: Annals of Nutrition and Metabolism - Category: Nutrition Source Type: research
Authors: Medrano Navarro AL, Justel Enríquez A, Alameda Serrano J, Blasco Lamarca Y, Sáenz Abad D, Gimeno Orna JA Abstract BACKGROUND AND AIMS: Our aim was to assess the usefulness of KDIGO 2012 risk classification to predict total and cardiovascular mortality in type 2 diabetes mellitus (DM2). MATERIAL AND METHODS: Prospective cohort study that included DM2 patients. Clinical end-points were total and cardiovascular mortality. The main predictive variable was KDIGO risk classification, which is a combination of urinary albumin excretion and glomerular filtration rate. The predictive value was eva...
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
Publication date: Available online 19 March 2019Source: SeizureAuthor(s): Ilaria Lagorio, Federico Zara, Salvatore Striano, Pasquale StrianoAbstractFamilial adult myoclonic epilepsy (FAME), also described with different acronyms (ADCME, BAFME, FEME, FCTE and others), is a high-penetrant autosomal dominant condition featuring cortical hand tremors, myoclonic jerks, and occasional/rare convulsive seizures. Prevalence is unknown since this condition is often under-recognized, but it is estimated to be less than 1/35,000. The disease usually starts in the second decade of life and has been genetically associated with at least ...
Source: Seizure - Category: Neurology Source Type: research
Publication date: May 2019Source: Epilepsy &Behavior, Volume 94Author(s): Ann Hempel, Michael Frost, Nitin AgarwalAbstractFew studies have examined treatment response in electrical status epilepticus in sleep (ESES), and fewer still have evaluated the effect of corticosteroid treatment employing a pulse-dose regimen. The aim of this study was to examine the effectiveness of pulse-dose prednisone in treating language and behavioral disturbances that often accompany ESES. The sample included 17 patients age 5 to 10 years at time of baseline electroencephalogram (EEG) and neuropsychological assessments. For all patients...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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