Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate Lymphoid Cell-Mediated Barrier Protection and Intestinal T Cell Activation during Colitis

Inflammatory bowel disease (IBD) results from a dysregulated interaction between the microbiota and a genetically susceptible host. Castellanos et  al. show a protective role for microbial induction of the IBD-linked protein TL1A in promoting ILC3 barrier immunity and uncover a pathogenic role for TL1A-induced expression of OX40L on ILC3s in driving chronic T cell colitis.

Source: Immunity - December 11, 2018 Category: Allergy & Immunology Authors: Jim G. Castellanos, Viola Woo, Monica Viladomiu, Gregory Putzel, Svetlana Lima, Gretchen E. Diehl, Andrew R. Marderstein, Jorge Gandara, Alexendar R. Perez, David R. Withers, Stephan R. Targan, David Q. Shih, Ellen J. Scherl, Randy S. Longman Tags: Article Source Type: research