Cancers, Vol. 10, Pages 506: Targeting BRCA Deficiency in Breast Cancer: What are the Clinical Evidences and the Next Perspectives?
Cancers, Vol. 10, Pages 506: Targeting BRCA Deficiency in Breast Cancer: What are the Clinical Evidences and the Next Perspectives?
Cancers doi: 10.3390/cancers10120506
Authors:
Emanuel Nicolas
François Bertucci
Renaud Sabatier
Anthony Gonçalves
Breast cancers (BC) associated with germline mutations of BRCA1/2 represent 3–5% of cases. BRCA1/2-associated BC have biological features leading to genomic instability and potential sensitivity to DNA damaging agents, including poly(ADP-ribose) polymerase (PARP) and platinum agents. In this review, we will summarize clinical trials of chemotherapy and PARP inhibitors (PARPi), alone or in combination, at the early or late stage of BRCA1/2-associated BC. We will also present the mechanisms of resistance to PARPi as well as the new therapeutic strategies of association with PARPi. Finally, we will discuss under which conditions the use of DNA damaging agents can be extended to the BRCA1/2-wild type population, the BRCAness concept.
Source: Cancers - Category: Cancer & Oncology Authors: Emanuel Nicolas Fran çois Bertucci Renaud Sabatier Anthony Gon çalves Tags: Review Source Type: research