Molecules, Vol. 23, Pages 3274: Four New Depsides Isolated from Salvia miltiorrhiza and Their Significant Nerve-Protective Activities
Molecules, Vol. 23, Pages 3274: Four New Depsides Isolated from Salvia miltiorrhiza and Their Significant Nerve-Protective Activities
Molecules doi: 10.3390/molecules23123274
Authors:
Qinghao Jin
Xinyi Hu
Yanping Deng
Jinjun Hou
Min Lei
Hongjian Ji
Jing Zhou
Hua Qu
Wanying Wu
Dean Guo
By investigating of the roots of Salvia miltiorrhiza, which is one of the most widely used Chinese herbs, we used phytochemical methods successfully to obtain twelve depsides: four depsides (1–4) that were previously undescribed, along with eight known ones (5–12). Their structure characteristics were assessed by HR-ESIMS, CD, NMR (1H, 13C, HSQC, HMBC) data analyses. These four newly isolated compounds (1–4), as well as the other eight compounds (5–12), show extraordinary protective effects on hydrogen peroxide-induced apoptosis in HS-SY5Y cells. Among them, depside 4 and depside 6 displayed more obviously protective effects than others.
Source: Molecules - Category: Chemistry Authors: Qinghao Jin Xinyi Hu Yanping Deng Jinjun Hou Min Lei Hongjian Ji Jing Zhou Hua Qu Wanying Wu Dean Guo Tags: Article Source Type: research
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