Molecules, Vol. 23, Pages 3274: Four New Depsides Isolated from Salvia miltiorrhiza and Their Significant Nerve-Protective Activities

Molecules, Vol. 23, Pages 3274: Four New Depsides Isolated from Salvia miltiorrhiza and Their Significant Nerve-Protective Activities Molecules doi: 10.3390/molecules23123274 Authors: Qinghao Jin Xinyi Hu Yanping Deng Jinjun Hou Min Lei Hongjian Ji Jing Zhou Hua Qu Wanying Wu Dean Guo By investigating of the roots of Salvia miltiorrhiza, which is one of the most widely used Chinese herbs, we used phytochemical methods successfully to obtain twelve depsides: four depsides (1–4) that were previously undescribed, along with eight known ones (5–12). Their structure characteristics were assessed by HR-ESIMS, CD, NMR (1H, 13C, HSQC, HMBC) data analyses. These four newly isolated compounds (1–4), as well as the other eight compounds (5–12), show extraordinary protective effects on hydrogen peroxide-induced apoptosis in HS-SY5Y cells. Among them, depside 4 and depside 6 displayed more obviously protective effects than others.
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
More News: China Health | Herbs