Incidence of oxandrolone induced hepatic transaminitis in patients with burn injury

Oxandrolone, a synthetic derivative of testosterone, has become a standard of care treatment in patients with severe burn injury at many comprehensive burn centers. The testosterone derivative exhibits high anabolic and low androgenic effects, and has been used for its ability to counterbalance the hypermetabolism and hypercatabolism associated with severe burn injuries [1 –4]. Oxandrolone promotes skeletal muscle growth in burn patients by improving the efficiency of amino acid utilization and increasing overall muscle protein synthesis [5–7].

Source: Burns : Journal of the International Society for Burn Injuries - December 10, 2018 Category: Cosmetic Surgery Authors: Brittany Kiracofe, Rebecca Coffey, Larry M. Jones, J. Kevin Bailey, Sheela Thomas, Kyle Porter, Claire V. Murphy Source Type: research