Lens dose-response prediction modeling and cataract incidence in retinoblastoma patients after lens-sparing or whole-eye radiotherapy
We report the first clinical data demonstrating significantly lower cataract formation rate in retinoblastoma patients treated with lens-sparing radiotherapy in the modern era. Through dose-response modeling, we validate a mean lens dose threshold of 7 Gy to keep the cataract risk under 25%. Although radiotherapy is used significantly less often for Rb due to advances in chemotherapy delivery options, these findings are relevant for refining lens dose constraints.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Steven M. Nguyen, Julian Sison, Marjorie Jones, Jesse L. Berry, Jonathan W. Kim, A. Linn Murphree, Vanessa Salinas, Arthur J. Olch, Eric L. Chang, Kenneth K. Wong Tags: Clinical Investigation Source Type: research
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