Lens dose-response prediction modeling and cataract incidence in retinoblastoma patients after lens-sparing or whole-eye radiotherapy

We report the first clinical data demonstrating significantly lower cataract formation rate in retinoblastoma patients treated with lens-sparing radiotherapy in the modern era. Through dose-response modeling, we validate a mean lens dose threshold of 7 Gy to keep the cataract risk under 25%. Although radiotherapy is used significantly less often for Rb due to advances in chemotherapy delivery options, these findings are relevant for refining lens dose constraints.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Clinical Investigation Source Type: research