Analysis of Single Nucleotide Polymorphisms in the Gamma Block of the Major Histocompatibility Complex in Association with Clinical Outcomes of Hematopoietic Cell Transplantation: A CIBMTR Study

Human leukocyte antigen (HLA) mismatches have the strongest impact on clinical outcomes following unrelated hematopoietic cell transplantation (HCT).1,2 In addition, in otherwise genotypically HLA matched unrelated donor HCT; major histocompatibility complex (MHC) haplotype mismatches have been associated with higher risk of graft versus host disease (GVHD) and with lower risk of disease relapse.3 The MHC region spans approximately 3.8 megabases (Mb) of the short arm of chromosome 6 at 6p21.3 and includes over 269 loci.

Source: Biology of Blood and Marrow Transplantation - December 8, 2018 Category: Hematology Authors: Medhat Askar, David Sayer, Tao Wang, Michael Haagenson, Stephen R. Spellman, Stephanie J. Lee, Abeer Madbouly, Katharina Fleischhauer, Katharine C. Hsu, Michael R. Verneris, Dawn Thomas, Aiwen Zhang, Ronald M. Sobecks, Navneet S. Majhail, CIBMTR ® Immuno Source Type: research