Trends in Drug Use-Associated Infective Endocarditis and Heart Valve Surgery, 2007 to 2017: A Study of Statewide Discharge Data.

Conclusion: DUA-IE hospitalizations and valve surgeries increased more than 12-fold, and nearly half of all IE valve surgeries were performed in patients with DUA-IE. The swell of patients with DUA-IE is reshaping the scope, type, and financing of health care resources needed to effectively treat IE. Primary Funding Source: National Institutes of Health. PMID: 30508432 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - Category: Internal Medicine Authors: Tags: Ann Intern Med Source Type: research

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Publication date: December 2019Source: Journal of Transport &Health, Volume 15Author(s): Lake Sagaris, Daniel LanfrancoAbstractAn abundant literature has examined the usefulness of “safe routes to school” programs to increase active transport (mainly walking and cycling) and with it levels of physical activity, hence health. To date, these have been applied mainly in the Global North, where they are supported by national networks and government.Conditions in developing countries differ. While the obesity epidemic is rife, the sustainability trio of walk-bike-bus/Metro account for high percentages (66% or mo...
Source: Journal of Transport and Health - Category: Occupational Health Source Type: research
Conclusions: Religious support from friends and believing religious beliefs are essential in life appeared to be protective factors against MDE among non-users. Further research is needed to explore protective factors that can effectively address the association between opioid misuse and mental health and be incorporated into health interventions targeting the opioid epidemic. PMID: 31718382 [PubMed - as supplied by publisher]
Source: Substance Use and Misuse - Category: Addiction Tags: Subst Use Misuse Source Type: research
All children attending preschool or higher in the country must be immunized, with fines for parents who do not comply, under a law that is to take effect next spring.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Germany Measles Vaccination and Immunization Politics and Government Epidemics Children and Childhood Source Type: news
The objective of this study was to examine Medicaid and commercially insured mother-infant pairs to determine demographic and clinical characteristics associated with NAS length of stay (LOS). Research Design: This observational, descriptive case-series study utilized administrative claims from HealthCore Integrated Research Database to measure maternal characteristics for 6 months before delivery, and neonatal characteristics and health care service utilization for 3 months after NAS diagnosis. Bootstrapped regressions were used to model LOS. Results: The sample included 1807 mother-infant pairs. Most infants (79%) ...
Source: Medical Care - Category: Health Management Tags: Patient-centered Care Source Type: research
Abstract Sri Lanka reports a large epidemic of cutaneous leishmaniasis (CL) caused by an atypical L. donovani while regional leishmaniasis elimination drive aims at achieving its targets in 2020. Visceralization, mucotrophism, and CL associated poor treatment response were recently reported. Long-term clinico-epidemiological trends (2001-2013) in this focus were examined for the first time. Both constant and changing features were observed. Sociodemographic patient characteristics that differ significantly from those of country profile, microchanges within CL profile, spatial expansion, constant biannual seasonal ...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
(Michigan State University) The US opioid epidemic is still raging -- it's particularly pronounced in low-income areas and in those where people lack access to health care services, which includes cities in Michigan and across the Rust Belt. But the effectiveness of efforts to provide treatment and recovery options to those who need it most -- that is, in locations with the greatest number of deaths from opioid overdose -- has been unclear.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
We report the case of a 47-year-old man who was diagnosed with severe right ventricular outflow tract (RVOT) stenosis due to a space-occupying lesion; the diagnosis was made using computed tomography. He underwent mass reduction, pulmonary valve replacement, and RVOT reconstruction with a bovine pericardial patch. The pathological diagnosis was undifferentiated pleomorphic sarcoma originating from the myocardium. As the mass resection was incomplete, he received heavy particle therapy. He did not want to receive adjuvant chemotherapy. Four months later, severe RVOT stenosis recurred because the residual mass had invaded th...
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
The objective of this observational study was to investigate the effectiveness and tolerability of hydroxychloroquine (HCQ) in T2DM patients uncontrolled on multiple OHA and despite high sugar level not willing to initiate insulin therapy in a real-world clinical setting. METHODS: A prospective, investigator-initiated, observational, single-centred study was conducted where 250 patients (18-65 years) with T2DM for more than 5 years, with uncontrolled glycemia despite on a combination of multiple OHA, HbA1c between ≥7% and 130 mg/dL or PPG>180 mg/dL and BMI between>25 and
Source: Current Diabetes Reviews - Category: Endocrinology Authors: Tags: Curr Diabetes Rev Source Type: research
AbstractPurpose of reviewAs the number of surgical and transcatheter valve replacements continue to increase in the aging population, so does the incidence of paravalvular leak (PVL). Given its impact on morbidity and mortality, this article will focus on the epidemiology, clinical presentation, diagnostic assessment, and available treatments for PVL.Recent findingsDespite being performed on inoperable and typically higher risk patients, short-term complication rates of transcatheter PVL closure appear relatively low (
Source: Current Treatment Options in Cardiovascular Medicine - Category: Cardiology Source Type: research
Diabetes mellitus is a growing problem worldwide; however, only 23% of low-income countries have access to insulin, and ironically it costs higher in such countries than high-income ones. Therefore, new strategies for insulin and insulin analogs production are urgently required to improve low-cost access to therapeutic products, so as to contain the diabetes epidemic. SCI-57 is an insulin analog with a greater affinity for the insulin receptor and lower thermal degradation than native insulin. It also shows native mitogenicity and insulin-like biological activity. In this work, SCI-57 was transiently expressed in the Nicot...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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