A regulatory variant in TBX2 promoter is related to the decreased susceptibility of congenital heart disease in the Han Chinese population

ConclusionThe minor C allele of rs4455026 inTBX2 promoter region was related with lower CHD susceptibility in the Han Chinese population via repressing its transcriptional activity.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research

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ConclusionPICM occurred in 4% of TOF patients receiving RV pacing, and there was no association between frequent RV pacing and temporal decline in LVEF. Further studies are required to determine the long-term impact of RV pacing in the TOF population, and explore optimal treatment strategies.
Source: IJC Heart and Vasculature - Category: Cardiology Source Type: research
Hypertension is possibly the most powerful, modifiable risk factor for the development of heart failure. Chronic hypertension drives cardiac remodeling within the left ventricle resulting in hypertensive heart disease, which ultimately manifests as heart failure. Early detection and appropriate management are necessary to prevent heart failure as well as other cardiovascular diseases. Achieving blood pressure goals in conjunction with using evidence-based treatments can improve clinical outcomes for patients with comorbid hypertension and heart failure.
Source: Heart Failure Clinics - Category: Cardiology Authors: Source Type: research
This article discusses the basic science and clinical data that support the hypothesis that these changes pose pathophysiologic and potential novel therapeutic challenges.
Source: Heart Failure Clinics - Category: Cardiology Authors: Source Type: research
The post Why wheat causes heart disease appeared first on Dr. William Davis.
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle cardiac cholesterol gluten-free grain-free grains heart attack heart disease myocardial Source Type: blogs
Conclusion: Chest pain is mainly due to benign causes and is a recurrent symptom in a high percentage of patients, associated with re-admission and school absenteeism.What is Known:•Chest pain is a relatively common cause of admission to the Emergency Department.•It is mainly due to benign causes and is among the most common reasons for referral to the pediatric cardiologist.What is New:•Chest pain is a recurrent symptom associated with re-admission and school absenteeism.•As a family history of cardiac disease or exertional symptoms are a well-known red flag for chest pain of cardiac origin, school abs...
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research
AbstractMajor perioperative cardiovascular events are important causes of morbidity in pediatric patients with congenital heart disease who undergo reparative surgery. Current preoperative clinical risk assessment strategies have poor accuracy for identifying patients who will sustain adverse events following heart surgery. There is an ongoing need to integrate clinical variables with novel technology and biomarkers to accurately predict outcome following pediatric heart surgery. We tested whether preoperative levels of miRNAs-208a can serve as such a biomarker. Serum samples were obtained from pediatric patients immediate...
Source: Journal of Cardiovascular Translational Research - Category: Cardiology Source Type: research
ConclusionsDiabetic nephropathy was common among Chinese patients with type 2 diabetes in primary care in Hong Kong. Early identification and control of the modifiable risk factors are of upmost importance in preventing the complication.
Source: Journal of Diabetes and Metabolic Disorders - Category: Endocrinology Source Type: research
This study aims to recruit at least 120 cases and 360 controls matched by age, ethnicity, gender, deprivation, district, and time period. For data collection, a comprehensive pre-tested questionnaire focussed on exposures during the four weeks prior to illness or interview will be used. Linked data include previous hospitalisations, dental records, and school characteristics. Specimen collection includes a throat swab (Group A Streptococcus), a nasal swab (Staphylococcus aureus), blood (vitamin D, ferritin, DNA for genetic testing, immune-profiling), and head hair (nicotine). A major strength of this study is its comprehen...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Protocol Source Type: research
AbstractSocioeconomic inequalities in mortality are a challenge for public health around the world, but appear to be resistant to policy-making. We aimed to identify European countries which have been more successful than others in narrowing inequalities in mortality, and the factors associated with narrowing inequalities. We collected and harmonised mortality data by educational level in 15 European countries over the last 25  years, and quantified changes in inequalities in mortality using a range of measures capturing different perspectives on inequality (e.g., ‘relative’ and ‘absolute’ ineq...
Source: European Journal of Epidemiology - Category: Epidemiology Source Type: research
Source: Clinical Epidemiology - Category: Epidemiology Tags: Clinical Epidemiology Source Type: research
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