Effect of Progesterone on Expression of MMP7 and MMP13 in Lungs of Female Mice.

In this study we investigated the impact of pregnancy doses of progesterone hormone on the expression of a couple of matrix metalloproteinase (MMPs), which are known to be involved in tissue remodeling of lungs in health and disease, namely MMP7 and 13. Pregnancy maintenance dose of progesterone was administered to female BALB/c mice for 21 and 28 days, the control group received PBS for the same days. After removal of the lungs and RNA extraction, quantitative real-time PCR was done using specific primers for MMP7 and MMP13. We found that progesterone can slightly (not significantly) decrease the expression of MMP13 but had no effect on MMP7. Our results shows that progesterone has minimal effect on the expression of matrix metalloproteinase7 and matrix metalloproteinase 13, but it may still have an effect on corresponding tissue inhibitor of matrix metalloproteinases (TIMPs) or other components of the Extracellular matrix  which remains to be elucidated. Also, the effect of progesterone on these MMPs can be further studied in a fibrosis model. PMID: 30518190 [PubMed - in process]
Source: Iranian Journal of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Iran J Allergy Asthma Immunol Source Type: research

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The prevalence of food allergy has been steadily rising worldwide with the highest incidence noted among younger children, and increasingly recognized as a growing public concern. Allergic reactions to foods often occur on the first known ingestion, suggesting that exposure of offspring to food allergens may occur in utero and/or through breast milk. This creates a milieu that shapes the neonatal immune response to these allergens. However, the effects of maternal allergen exposure and maternal sensitization with allergens on development of allergies in offspring remain controversial. This review discusses recent advances ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
The lymphohematopoietic cells originating from feto-maternal trafficking during pregnancy may cause microchimerism and lead to materno-fetal graft versus host disease (GVHD) in severe combined immunodeficiency...
Source: Allergy, Asthma and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Case report Source Type: research
ConclusionsThe benefits of FENO-based management are attenuated among obese mothers and those with excess GWG, indicating the importance of weight management in contributing to improved asthma management in pregnancy.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Asthma is often not well controlled during pregnancy, especially among publicly-insured women, according to a U.S. study.Reuters Health Information
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Pulmonary Medicine News Source Type: news
ConclusionsThe benefits of FENO -based management are attenuated among obese mothers and those with excess GWG, indicating the importance of weight management in contributing to improved asthma management in pregnancy.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
CONCLUSIONS: Outcome-specific criteria are an important part of a systematic review and will facilitate study evaluations by epidemiologists with experience in evaluating studies using systematic review methods who may not have extensive discipline-specific experience in the outcomes being reviewed. PMID: 31299560 [PubMed - as supplied by publisher]
Source: Environment International - Category: Environmental Health Authors: Tags: Environ Int Source Type: research
Researchers identified nearly 400 common medical practices and theories that were contradicted by rigorous studies. Here are some of the most notable findings.
Source: NYT - Category: American Health Authors: Tags: Medicine and Health Doctors Asthma Allergies Peanuts Pregnancy and Childbirth Testosterone Babies and Infants Memory Omega-3 Fatty Acids Oils and Fats Clinical Trials Knees Physical Therapy Journal of the American Medical Assn Source Type: news
Researchers identified nearly 400 common medical practices and theories that were contradicted by rigorous studies. Here are some of the most notable findings.
Source: NYT - Category: American Health Authors: Tags: Medicine and Health Doctors Asthma Allergies Peanuts Pregnancy and Childbirth Testosterone Babies and Infants Memory Omega-3 Fatty Acids Oils and Fats Clinical Trials Knees Physical Therapy Journal of the American Medical Assn Source Type: news
ConclusionsPoorly controlled asthma is more frequent among publicly versus privately insured pregnancies in the United States. Dispensing of long-term controller medications during pregnancy remains low, even for symptomatic patients.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Publication date: Available online 22 June 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Erika J. Yoo, Nora L. Lee, Kelly P. Huang, Lara T. Kose, Deval Desai, Lauren A. Plante, Edward S. Schulman
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
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