Downregulation of RTN1-C attenuates MPP+-induced neuronal injury through inhibition of mGluR5 pathway in SN4741 cells.

In conclusion, our data suggest that downregulation of RTN1-C protects SN4741 cells against MPP+ through mGluR5-mediated preservation of Ca2+ homeostasis. Therefore, RTN1-C might represent a therapeutic target for the treatment of neuronal injury in experimental PD models. PMID: 30521940 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30521940?dopt=Abstract

Source: Brain Research Bulletin - December 3, 2018 Category: Neurology Authors: Chang J, Zhang XL, Yu H, Chen J Tags: Brain Res Bull Source Type: research

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