[Current Status of Health Foods Including Their Interactions with Drugs and Adverse Events].

[Current Status of Health Foods Including Their Interactions with Drugs and Adverse Events]. Yakugaku Zasshi. 2018;138(12):1511-1516 Authors: Saito Y Abstract Although many people (and patients) in Japan currently consume health foods such as supplements, few have proper knowledge of their usefulness and safety. In December 2015, the Food Safety Commission of Japan issued a report and 19 messages mainly on the safety of health foods to disseminate appropriate knowledge to consumers. The report divided health food risks into three categories: 1) risks as food (e.g., increased lung cancer risk in smokers consuming excess β-carotenoid); 2) risks as health foods (e.g., short consumption history, drug contamination, poor quality of active ingredients, and interactions with drugs); and 3) risks due to a lack of adequate scientific information on health foods. The risk of insulin autoimmune syndrome caused by α-lipoic acid is relatively high among Japanese individuals because its onset is associated with HLA-DRB1*04:06, an HLA allele occurring frequently in East Asian populations. As for health food-drug interactions, an important pharmacokinetic interaction between drugs and St. John's Wort was described from several viewpoints: different effects on drugs within the same class (depending on the metabolic pathway); interindividual differences in its effects; importance of considering active metabolite involvement; and time course of inter...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research