Contribution of the OC Sensor ® immunoassay in comparison to the Hemoccult II ® guaiac-test in organized colorectal cancer screening

AbstractColorectal cancer (CRC) is a major cause of cancer-related death of worldwide with high incidence and mortality rate, accessible to a screening program in France, first with guaiac- based fecal occult blood test (g-FOBT) then with fecal immunochemical tests (FIT), since 2015, because of better accuracy. The aim of our study was to compare the characteristics of screen-detected lesions in two successive CRC screening campaigns, using two different tests (Hemoccult II® and OC Sensor®) in the department of Maine-et-Loire, and to precise the performance of these tests [participation rate, detection rates (DR), positive predictive value (PPV)]. Participants, invited by CAP SANTE 49, with polyps or cancer at the colonoscopy after a positive screening test between 01/01/2013 and 31/12/2016 were included. A guaiac-based fecal occult blood test (g-FOBT) was used from January 2013 to December 2014 and a FIT was used from June 2015 to December 2016). 2575 participants, 642 in g-FOBT group and 1933 in FIT group had lesions. Participation rate was not different between tests (p = 0.104), whereas DR and PPV were statistically higher in FIT for all lesions (2.61, 95% CI [2.50–2.70] vs 0.93, 95% CI [0.90–1.00],p <  0.0001 and 64.84, 95% CI [63.10–66.60], 50.00, 95% CI [47.30–52.70],p <  0.0001 respectively). FIT detects more precancerous lesions (adenomas,p <  0.001, and advanced adenomas,p <  0.001) than g-FOBT but g-FOBT detects more serrat...
Source: European Journal of Epidemiology - Category: Epidemiology Source Type: research