TLR9 rs352139 genetic variant promotes tacrolimus elimination in Chinese liver transplant patients during the early posttransplantation period

ConclusionsDonor TLR9 rs352139 genetic variant facilitated tacrolimus elimination during the early stage after LT in Chinese patients, which might be related to the upregulation of CYP3A5 enzyme via the NF ‐kB/PXR signaling pathway.This article is protected by copyright. All rights reserved.

Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - December 8, 2018 Category: Drugs & Pharmacology Authors: Baochi Ou, Yuan Liu, Tao Zhang, Yahuang Sun, Jiayi Chen, Zhihai Peng Tags: Original Research Article Source Type: research