PET tracers help guide breast cancer therapies

PET imaging tracers that track breast cancer enzymes could help guide treatment...Read more on AuntMinnie.comRelated Reading: SNMMI: Fluciclovine-PET changes prostate treatment Mammi-PET finds tiny breast lesions -- but could improve Fused MRI and PET improve specificity of breast MRI PEM performs well against breast MRI, whole-body PET NCPIC to provide PET breast scans for uninsured
Source: Headlines - Category: Radiology Source Type: news

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PEGylated Poly(α-lipoic acid) Loaded with Doxorubicin as a pH and Reduction Dual Responsive Nanomedicine for Breast Cancer Therapy. Biomacromolecules. 2018 Oct 22;: Authors: Yang H, Shen W, Liu W, Chen L, Zhang P, Xiao C, Chen X Abstract Disulfide-containing nanoparticles are promising vehicles for anticancer drug delivery. However, the preparation of disulfide-containing nanoparticles usually relies on complex synthetic procedures. In the present work, a PEGylated poly(α-lipoic acid) (mPEG-PαLA) copolymer was facilely synthesized and used for pH and reduction dual responsive drug de...
Source: Biomacromolecules - Category: Biochemistry Authors: Tags: Biomacromolecules Source Type: research
In conclusion, the synthesized DOX@nanocomposite can be applied in theranostic applications and anticancer drug delivery owing to admissible properties. PMID: 30307331 [PubMed - as supplied by publisher]
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
In conclusion, we visualized that the synthesized DTX-nanomicelles can be used as an anticancer drug delivery system considering their useful biocompatibility and excellent physicochemical properties.Graphical abstract
Source: European Polymer Journal - Category: Chemistry Source Type: research
Abstract Commonly, acquired resistances to anticancer drug are mediated by overexpression of a membrane-associated protein that encode via multi-drug resistance gene-1 (MDR1). Herein, the mRNA-cleaving DNAzyme that targets the mRNA of MDR1 gene in doxorubicin-resistant breast cancer cell line (MCF-7/DR) loaded on the chitosan β-cyclodextrin complexes was used as a tropical agent. Chitosan/β-cyclodextrin complexes were used to deliver DNAzymes into cancer cells. Determination of the physicochemical characteristics of the particles was done by photon correlation spectroscopy and scanning electron microscop...
Source: Applied Biochemistry and Biotechnology - Category: Biochemistry Authors: Tags: Appl Biochem Biotechnol Source Type: research
Publication date: Available online 7 July 2018Source: Journal of Molecular LiquidsAuthor(s): Samira Malekmohammadi, Hassan Hadadzadeh, Zahra AmirghofranAbstractThe purpose of this study is to develop a targeted drug delivery system containing folic acid-conjugated dendritic amino mesoporous silica nanoparticles (DFMSNs) loaded with a cyclometallated gold(III) complex, [Au(bzpy)Cl2] (bzpy = 2-benzylpyridine), as a cytotoxic agent (Au(drug)@DFMSNs). The products, including the Au(III) complex, DFMSNs, and Au(drug)@DFMSNs, were characterized by transmission electron microscopy (TEM), field-emission scanning electron micro...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
Conclusions: This manuscript demonstrated that the Tf-conjugated HMSNs could enhance the delivery efficiency of anticancer drugs, while simultaneously alleviating the adverse side effects. The current study presents a promising integrated delivery system toward effective and safe cancer treatment.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
Abstract The current experiment reveals the anticancer properties of silver nanoparticles (AgNPs) synthesized using aqueous leaf extract of Cichorium intybus, a significant medicinal plant. The characteristics of AgNPs were continuously studied by powder X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), zeta potential, transmission electron microscopy (TEM), scanning electron microscopy (SEM), and energy-dispersive spectroscopy (EDS) analysis. Current microscopic results show that produced AgNPs were spherical in shape with an average size of 17.17 nm. A strong peak between 2 and 4 ...
Source: Biological Trace Element Research - Category: Biology Authors: Tags: Biol Trace Elem Res Source Type: research
Conclusion: D-TiO2 NPs as UV photosensitizer for CR induced PDT were prepared, and exhibited high cellular uptake and low cytotoxicity to 4T1 cells. Ga-68 demonstrated significantly better tumor suppression than F-18 against 4T1 cancer cells both in vitro and in vivo, suggesting that Gallium-68 was very attractive for depth-independent cancer therapy without using any external light source.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Basic Science Posters (Oncology) Source Type: research
535Objectives: Targeted radionuclide therapy (TRT) has recently gained great momentum due to the promising results achieved in the treatment of neuroendocrine and prostate cancer. However, similar approaches elude breast cancer therapies given the lack of radiopharmaceuticals that effectively target breast cancer. Our goal is to develop a theranostic strategy that uses a novel alkylphosphocholine analog (NM600) labeled with 86Y for targeted PET imaging and 177Lu for TRT in a syngeneic murine model of breast cancer. Methods: NM600 was synthesized by conjugating 18-(p-aminophenyl)octadecyl phosphocholine to the chelator DOTA...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Preclinical Probes for Oncology II Source Type: research
CONCLUSION: The results provide strong rationale for further exploration of the newly developed CUR-SLN to be utilized as a potent chemotherapeutic agent in cancer therapy. PMID: 29732970 [PubMed - as supplied by publisher]
Source: Current Drug Delivery - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Deliv Source Type: research
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