Autologous Stem Cell Transplant for IgM Associated AL amyloidosis

Amyloidosis related to an IgM monoclonal protein is a rare entity accounting for approximately 5% of patients with immunoglobulin light chain (AL) amyloidosis [1,2]. Patients with IgM related AL amyloidosis tend to present with lower levels of serum free light chains, have less cardiac involvement and more neurological involvement compared to those with non-IgM related AL amyloidosis [1 –3]. Therapy is generally extrapolated form regimens used for non-IgM related AL amyloidosis. However given the lymphoplasmacytic nature of the clonal disorder in these patients, regimens used to treat lymphoplasmacytic lymphoma have also been employed.

Source: Biology of Blood and Marrow Transplantation - December 7, 2018 Category: Hematology Authors: M Hasib Sidiqi, Francis K. Buadi, Angela Dispenzieri, Rahma Warsame, Martha Q. Lacy, David Dingli, Nelson Leung, Wilson I. Gonsalves, Prashant Kapoor, Taxiarchis V. Kourelis, William J. Hogan, Shaji K. Kumar, Morie A. Gertz Source Type: research