FibroScan detects cardiovascular damage in patients with NAFLD

Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research

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Serine-rich splicing factor 3 (SRSF3) plays a critical role in liver function and its loss promotes chronic liver damage and regeneration. As a consequence, genetic deletion of SRSF3 in hepatocytes caused progressive liver disease and ultimately led to hepatocellular carcinoma. Here we show that SRSF3 is decreased in human liver samples with nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), or cirrhosis that was associated with alterations in RNA splicing of known SRSF3 target genes. Hepatic SRSF3 expression was similarly decreased and RNA splicing dysregulated in mouse models of NAFLD and NASH...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
DAVID DAVIS:A year ago, after I resigned from my Cabinet job as Brexit Secretary, I had a routine medical. The doctor frowned, I had non-alcoholic fatty liver disease (NAFLD).
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Introduction: The development of patient journey for patients with Nonalcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) is a current challenge for outpatient liver centers. The early identification of high-risk patients with NAFLD/NASH require multidisciplinary approach in order to assure the appropriate specialistic referral in a personalized model of chronic care program.
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: P-10 Source Type: research
ConclusionAmong individuals with morbid obesity, the findings of this study are suggestive that liver fibrosis confirmed by histopathological examination is associated with  a slight impairment of left ventricular function. Further studies are needed to confirm this association.
Source: Obesity Surgery - Category: Surgery Source Type: research
Bariatric surgery is still not recommended to alleviate the long-term sequelae of non-alcoholic fatty liver disease (NAFLD) despite some evidence to suggest bariatric surgery can mitigate the risk of non-alcoholic steatohepatitis (NASH) and/or hepatocellular carcinoma. This current study is the first to use a propensity match analysis of a large cohort of bariatric surgery patients with non-surgery controls to show that patients who had undergone bariatric surgery had fewer new cases of NASH and HCC with extended follow up, and further risk adjustment also revealed bariatric surgery was associated with fewer cases of NASH ...
Source: American Journal of Surgery - Category: Surgery Authors: Source Type: research
ConclusionsEDA aggravates steatosis by striking balance between lipid deposition and elimination. It was a potential biomarker of NAFLD.
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
Contributors : R Maeso-Diaz ; J J Lozano ; J Gracia-SanchoSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusNASH is a severe form of NAFLD that can progress to cirrhosis and hepatocellular carcinoma and, its incidence has markedly increased in recent years. Current available animal models fail to reflect the whole spectrum of the disease. We herein designed a Barcelona NASH (BarNa) rat model using the combination of high fat&cholesterol diet with CCl4 inhalation for 10 weeks (NASH) or 24 weeks (NASH-CH). This model reflects the full spectrum of human NASH and present the main c...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Rattus norvegicus Source Type: research
llo Persico Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide and its incidence is definitely increasing. NAFLD is a metabolic disease with extensive multi-organ involvement, whose extra-hepatic manifestations include type 2 diabetes mellitus, cardiovascular disease, obstructive sleep apnea, chronic kidney disease, osteoporosis, and polycystic ovarian syndrome. Recently, further evidence has given attention to pathological correlations not strictly related to metabolic disease, also incorporating in this broad spectrum of systemic involvement hypothyroidism, psoriasis,...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research
Publication date: Available online 11 September 2019Source: Redox BiologyAuthor(s): Tao Zhou, Ling Chang, Yi Luo, Ying Zhou, Jianjun Zhang
Source: Redox Biology - Category: Biology Source Type: research
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and is characterized by excessive hepatic lipid accumulation. Many studies have suggested that lipid overload is the key initi...
Source: BMC Complementary and Alternative Medicine - Category: Complementary Medicine Authors: Tags: Research article Source Type: research
More News: Cardiology | Cardiovascular | Gastroenterology | Heart | Non-alcoholic Fatty Liver Diseases (NAFLD)