Time series analysis of gene changes and processes after burn with human gene expression profiles

Burns, especially large area of burn injury not only give rise to damage of the local skin and deep tissue, but can cause obvious changes of the body ’s internal organs and the system function, metabolism and morphology [1,2]. Systematic researches have shown that serious burn injury not only induce immune function and metabolism disorder, at the same time can cause DNA damage, apoptosis, and a series of pathophysiological changes [3–6]. The hypermetabolic response begins on the fifth day of post-injury, while the inflammatory response starts immediately after burn and persists for up to several months [7].
Source: Burns : Journal of the International Society for Burn Injuries - Category: Cosmetic Surgery Authors: Source Type: research