Silencing salusin β ameliorates heart failure in aged spontaneously hypertensive rats by ROS-relative MAPK/NF-κB pathways in the paraventricular nucleus

Sustained hypertension is a major cause of heart failure in aging hypertensive patients. Salusin β, a novel bioactive peptide of 20 amino acids, has been reported to participate in various cardiovascular diseases, including hypertension. We therefore hypothesized that central knockdown of salusin β might be effective for hypertension-induced heart failure treatment.

Source: International Journal of Cardiology - December 7, 2018 Category: Cardiology Authors: Hong-Bao Li, Xiao-Jing Yu, Juan Bai, Qing Su, Mo-Lin Wang, Chan-Juan Huo, Wen-Jie Xia, Qiu-Yue Yi, Kai-Li Liu, Li-Yan Fu, Guo-Qing Zhu, Jie Qi, Yu-Ming Kang Source Type: research