Dose response and stability of water equivalent PRESAGE ® dosimeters for synchrotron radiation therapy dosimetry.

Dose response and stability of water equivalent PRESAGE® dosimeters for synchrotron radiation therapy dosimetry. Phys Med Biol. 2018 Dec 06;63(23):235027 Authors: Gagliardi FM, Franich RD, Geso M Abstract This research investigated the dose response and post-irradiation stability of water-equivalent PRESAGE® dosimeters exposed to synchrotron radiation. Water-equivalent PRESAGE® dosimeters were irradiated up to 1000 Gy in a synchrotron x-ray beam with a mean energy of 95.3 keV. The change in optical density was measured using UV/visible spectrophotometry pre- and post-irradiation using a wavelength of 630 nm. Dose response was found to be approximately linear from 0-200 Gy with saturation occurring above 300 Gy. The post-irradiation stability was determined by measuring the change in optical density at 10, 30, 60, 180, 420 min and 7, 21 and 33 d post-irradiation for three groups of dosimeters stored at different temperatures. Each group had two dosimeters irradiated at 50, 100, 200 and 300 Gy and each group was stored at a different temperature following irradiation: room temperature (22 °C), 4 °C and  -18 °C. The optimal time for readout of the dosimeters varied with the post-irradiation storage temperature. The room temperature group had an optimal time-to-readout of 10 min for maximum signal before fading, while the 4 °C group was reasonably stable from 90 min to 1 week. The&t...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research

Related Links:

This study recruited two centers with expertise in treating pediatric brain tumors with robotic radiation delivery system photon therapy and proton therapy, respectively, to study the plan quality and the dose deposition characteristics of robotic radiation delivery system photon and intensity modulated proton therapy (IMPT) plans.Methods and MaterialsA total of 18 patients clinically treated with robotic radiation delivery system were planned with intensity-modulated-proton-therapy (IMPT). Cases were planned per the standard of care of each institution but, respected the same planning objectives. The comparison was perfor...
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 19 September 2019Source: Chemico-Biological InteractionsAuthor(s): Prachurjya Dutta, Ravi Kumar Sahu, Tapan Dey, Manisha Datta Lahkar, Prasenjit Manna, Jatin KalitaAbstractInsect-based bioactive components are emerging as novel sources of drugs, effective against various diseases. Inflammation is considered to be an innate immune response developed by different organisms against foreign pathogens and cellular stress. However, repetitive elevated inflammation is considered to be responsible for development of many other diseases including colitis and arthritis. Due to the limited activitie...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Patients with non-Hodgkin's lymphoma who received radiation 30 days or less...Read more on AuntMinnie.comRelated Reading: ASTRO: AI predicts side effects from radiation therapy ASTRO: Is hormone therapy after prostate surgery needed? ASTRO: SABR generates immune response to prostate cancer ASTRO: Cervical cancer deaths rise as women's centers close ASTRO: Whole, partial breast RT yield similar cosmetic results
Source: Headlines - Category: Radiology Source Type: news
Conclusion: PSCCT is a rare but aggressive malignancy of the head and neck. Histopathologic and immunohistochemical evaluations are essential for diagnosis. While locoregional surgery and radiation therapy may improve the length of survival, the prognosis of patients with PSCCT is poor. Physicians should be mindful of this unique but deadly disease process, as early diagnosis and rapid treatment initiation are essential to optimize treatment outcomes. PMID: 31528145 [PubMed]
Source: Ochsner Journal - Category: General Medicine Tags: Ochsner J Source Type: research
Ionizing radiation (IR) can promote migration and invasion of cancer cells, but the basis for this phenomenon has not been fully elucidated. IR increases expression of glucose-regulated protein 78kDa (GRP78) on the surface of cancer cells (CS-GRP78), and this up-regulation is associated with more aggressive behavior, radioresistance, and recurrence of cancer. Here, using various biochemical and immunological methods, including flow cytometry, cell proliferation and migration assays, Rho activation and quantitative RT-PCR assays, we investigated the mechanism by which CS-GRP78 contributes to radioresistance in pancreatic du...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Molecular Bases of Disease Source Type: research
In this study we aimed to elicit the impact of different palliative therapy options on survival in a nationally representative sample of sinonasal cancer patients.MethodsNational Cancer Database 2004 ‐2015 data sets were queried for cases of primary sinonasal cancer (N = 380). Kaplan‐Meier analysis was utilized to determine median overall survival (M‐OS) and overall survival (OS) among the different treatment cohorts (pain management, palliative radiation therapy, palliative chemotherapy, palliative surgery, and combination therapy). Prognostic factors were elicited by comparing OS by log‐rank tests and subsequent ...
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Nature Reviews Clinical Oncology, Published online: 20 September 2019; doi:10.1038/s41571-019-0277-2In the past few years, efforts have been made to combine two approaches — immune-checkpoint inhibition and locally ablative radiation therapy — to treat patients with metastatic non-small-cell lung cancer. Herein we discuss the implications of two studies that support the existence of a systemic therapy augmented by radiotherapy (STAR) effect in this setting.
Source: Nature Reviews Clinical Oncology - Category: Cancer & Oncology Authors: Source Type: research
AbstractA large intra-cardiac tumor from the right ventricle to pulmonary trunk was detected by contrast-enhanced computed tomography and transthoracic echocardiography in a 59-year-old woman with progressive dyspnea on effort and acute congestive right-sided heart failure. Emergent surgical management was performed with cardiopulmonary bypass under cardiac arrest, however, tumor resection was incomplete, because it originated from the interventricular septum. Concomitant tricuspid valve replacement using a bioprosthesis was required due to the involvement of the septal leaflet of the tricuspid valve. Although large pulmon...
Source: General Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Radiation oncology firm Accuray has published an informational guide to help...Read more on AuntMinnie.comRelated Reading: Accuray to unveil system upgrades at ASTRO 2019 Accuray brings Radixact to Penn. Accuray posts higher sales in Q4 Accuray moves forward with China joint venture Accuray adds motion feature to radiation therapy system
Source: Headlines - Category: Radiology Source Type: news
Evidence reviewed for radiation therapy in adjuvant, neoadjuvant, definitive, and palliative settings
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Gastroenterology, Oncology, Pharmacy, Radiology, Journal, Source Type: news
More News: Biology | Physics | Radiation Therapy