2D and 3D real-time passive cavitation imaging of pulsed cavitation ultrasound therapy in moving tissues.

2D and 3D real-time passive cavitation imaging of pulsed cavitation ultrasound therapy in moving tissues. Phys Med Biol. 2018 Dec 06;63(23):235028 Authors: Suarez Escudero D, Goudot G, Vion M, Tanter M, Pernot M Abstract Pulsed cavitation ultrasound therapy (PCUT) is an effective non-invasive therapeutic approach in various medical indications that relies on the mechanical effects generated by cavitation bubbles. Even though limited by the poor contrast, conventional ultrasound B-Mode imaging has been widely used for the guidance and monitoring of the therapeutic procedure, allowing the visualization of the cavitation bubble cloud. However, the visualization of the bubble cloud is often limited in deep organs such as the liver and the heart and remains moreover completely subjective for the operator. Our goal is to develop a new imaging mode to better identify the cavitation cloud. Active and passive cavitation imaging methods have been developed but none of them has been able to locate the cavitation bubble created by PCUT in real-time and in moving organs. In this paper we propose a passive ultrasound imaging approach combined with a spatiotemporal singular value decomposition filter to detect and map the bubble cloud with high sensitivity and high contrast. In moving applications at a maximal motion speed of 10 mm s-1, the contrast-to-noise ratio for passive cavitation imaging is up to 10 times higher than for active cavitation ...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research