Mayo-led study: Drug reduces hot flashes, improves breast cancer survivor quality of life

(Mayo Clinic) Research led by oncologists Roberto Leon-Ferre, M.D. and Charles Loprinzi, M.D. of Mayo Clinic has found that the drug oxybutynin helps to reduce the frequency and intensity of hot flashes in women who are unable to take hormone replacement therapy, including breast cancer survivors. These findings were presented at the 2018 San Antonio Breast Cancer Symposium.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Abstract Women with germline BRCA1 or BRCA2 (BRCA) mutations, are recommended risk-reducing salpingo-oophorectomy (RRSO) prior to menopause. Surgical menopause has significant impact on patients' health and well-being. Subsequently, concerns about surgical menopause influence uptake of RRSO in high risk women. The role of hormone replacement therapy (HRT) in BRCA mutation carriers undergoing RRSO has been controversial. In the general population, premature surgical menopause is associated with worse quality of life and cognitive function, and increased risk of bone and cardiovascular disease; HRT continued until t...
Source: Gynecologic Oncology - Category: Cancer & Oncology Authors: Tags: Gynecol Oncol Source Type: research
A drug used in hormone replacement therapy can target estrogen receptors that have become resistant to breast cancer treatments.
Source: eLife - Category: Biomedical Science Tags: Cancer Biology Source Type: research
(CNN) — UK scientists have developed an online calculator that could enable doctors to more accurately predict a patient’s chance of developing breast cancer. If rolled out, the new tool could change the way in which the condition is treated. Among other things, details of family history, genetics, weight, alcohol consumption, age at menopause and use of hormone replacement therapy will all be considered by doctors when assessing a woman’s risk of developing breast cancer — the most common form of cancer in the UK. Each of these factors has “a small impact on the likelihood of developing the d...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News Breast Cancer CNN Local TV Source Type: news
ConclusionRates of mammography use over time do not necessarily reflect national guideline releases or establishment of organized screening programs.
Source: Cancer Causes and Control - Category: Cancer & Oncology Source Type: research
Abstract Rapid advance in oncology leads to increasing survival of oncologic patients. More and more of them live long enough to reach either the natural age of menopause or, as a side effect of their oncotherapy, experience the cessation of gonadal function, leading to premature ovarian insufficiency, with disturbing vasomotor symtoms and long-term negative cardiovascular and skeletal effects. Thus, an ever increasing number of cancer survivors search endocrinologic help in the form of hormone replacement therapy (HRT). The misinterpretation of the WHI (Women's Health Initiative) Study has lead to an irrational f...
Source: Pathology Oncology Research - Category: Pathology Authors: Tags: Pathol Oncol Res Source Type: research
ConclusionsThis analysis shows an association between HRT and the distribution of molecular subtypes of BC. However, no associations between other factors (e.g., age at diagnosis, body mass index, smoking status, age at menopause, number of deliveries, age at first delivery, breastfeeding history, or family history) were noted.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
This study included 3,609,569 screening mammograms performed from 2002 to 2015 in our organized breast cancer screening program, which actively invites women 50 –69 years of age. The association between women’s characteristics and the DCIS detection rate, the IBC detection rate and the odds ratio of DCIS among screen-detected cancers was assessed by logistic regression and generalized estimating equations with independent correlation matrix and sandwic h estimator.ResultsA total of 4173 DCIS and 15,136 IBC were screen-detected. Increasing women ’s age, current hormone replacement therapy use and high...
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
ConclusionThe calibrated PGsd measure provided significant associations with breast cancer comparable to those given by PD. The calibrated PGm performed slightly worse. These findings indicate that the calibration approach developed previously replicates under more general conditions.
Source: Academic Radiology - Category: Radiology Source Type: research
SAN ANTONIO ? Research led by oncologists Roberto Leon-Ferre, M.D. and Charles Loprinzi, M.D. of Mayo Clinic has found that the drug oxybutynin helps to reduce the frequency and intensity of hot flashes in women who are unable to take hormone replacement therapy, including breast cancer survivors. These findings were presented at the 2018 San [...]
Source: Mayo Clinic Research News - Category: Research Source Type: news
Conclusions: Although our results must be cautiously interpreted given small numbers within subgroups, they raise concern and emphasize the need for further evaluation on breast cancer risk of the increasingly common exposure to both oral contraceptives and hormone replacement therapy.
Source: Menopause - Category: OBGYN Tags: Commemorative Papers Source Type: research
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