Gait festination in parkinsonism: introduction of two phenotypes

AbstractGait festination is one of the most characteristic gait disturbances in patients with Parkinson ’s disease or atypical parkinsonism. Although festination is common and disabling, it has received little attention in the literature, and different definitions exist. Here, we argue that there are actually two phenotypes of festination. The first phenotype entails a primary locomotion disturbance , due to the so-called sequence effect: a progressive shortening of step length, accompanied by a compensatory increase in cadence. This phenotype strongly relates to freezing of gait with alternating trembling of the leg. The second phenotype results from a postural control problem (forward leaning of the trunk) combined with a balance control deficit (inappropriately small balance-correcting steps). In this viewpoint, we elaborate on the possible pathophysiological substrate of these two phenotypes of festination and discuss their management in daily clinical practice.
Source: Journal of Neurology - Category: Neurology Source Type: research

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Parkinson’s disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra. However, other non-dopaminergic neuronal systems such as the serotonergic system are also involved. Serotonergic dysfunction is associated with non-motor symptoms and complications, including anxiety, depression, dementia, and sleep disturbances. This pathology reduces patient quality of life. Interaction between the serotonergic and other neurotransmitters systems such as dopamine, noradrenaline, glutamate, and GABA controls the activity of striatal neurons and are particularly interesting for understan...
Source: Frontiers in Neuroanatomy - Category: Neurology Source Type: research
Condition:   Parkinson Disease Interventions:   Other: Game based treadmill Program;   Other: Conventional Gait Rehabilitation Sponsors:   University of Manitoba;   Weston Brain Institute Not yet recruiting
Source: - Category: Research Source Type: clinical trials
(McLean Hospital) McLean Hospital researchers have identified two molecules naturally produced by the body that stimulate the production of dopamine, the molecule that is in short supply in the brains of patients with Parkinson's disease.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
(University of Cambridge) Researchers have uncovered a link between the structure of the protein alpha-synuclein and its likelihood to misfold and aggregate.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
Neurorehabilitation is hampered due to social distancing and fear due to the chance of getting coronavirus disease, 2019 (COVID-19). Home-based or community-based and outpatient-based rehabilitation are restricted temporarily to protect both patients and caregivers from COVID-19 infection. Lack of physical activities during lockdown may lead to worsening of various motor and non-motor symptoms in patients with Parkinson's disease (PD) [1]. Therefore, to reduce the spread of the virus, digital rehabilitation (E-Rehabilitation) strategies should be adopted as an alternative mode to deliver rehabilitation services at the community level.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Tags: Correspondence Source Type: research
AbstractParkinson ’s disease (PD) is a neurodegenerative disorder characterized by loss of dopaminergic neurons. Dopaminergic system is interconnected with the hypothalamic–pituitary–thyroid axis. Dopamine (DA) upregulates thyrotropin releasing hormone (TRH) while downregulating thyroid stimulating hormone (TSH ) and thyroid hormones. Moreover, TRH stimulates DA release. PD is associated with impaired regulation of TSH and thyroid hormones (TH) levels, which in turn associate with severity and different subtypes of PD, while levodopa and bromocriptine treatment can interfere with hypothalamic–pituit...
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
This study aimed to characterize the neurophysiological correlates of gait in the human pedunculopontine nucleus (PPN) region and the globus pallidus internus (GPi) in Parkinson’s disease (PD) cohort. Though much is known about the PPN region through animal studies, there are limited physiological recordings from ambulatory humans. The PPN has recently garnered interest as a potential deep brain stimulation (DBS) target for improving gait and freezing of gait (FoG) in PD. We used bidirectional neurostimulators to record from the human PPN region and GPi in a small cohort of severely affected PD subjects with FoG desp...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
Sensors, Vol. 20, Pages 3189: An FPGA Based Tracking Implementation for Parkinson’s Patients Sensors doi: 10.3390/s20113189 Authors: Giuseppe Conti Marcos Quintana Pedro Malagón David Jiménez This paper presents a study on the optimization of the tracking system designed for patients with Parkinson’s disease tested at a day hospital center. The work performed significantly improves the efficiency of the computer vision based system in terms of energy consumption and hardware requirements. More specifically, it optimizes the performances of the background subtraction by segmenting...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
Condition:   Parkinson's Disease Intervention:   Biological: Human Amniotic Epithelial Stem Cells Sponsors:   Shanghai East Hospital;   Shanghai iCELL Biotechnology Co., Ltd, Shanghai, China Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Authors: Melchionda D, Varvara G, Perfetto D, Mascolo B, Avolio C Abstract Parkinson's disease (PD), which is not only a motor disease, is one of the most frequent neurodegenerative diseases and affects 1.5-2% of people worldwide. The role of its non motor-symptoms is of first importance on quality of life. Speech impairment is considered a part of motor impairment and is widespread in PD where most frequent speech impairment is Hypokinetic dysarthria, a disorder characterized by reduced articulation movements and phonetic monotony. Many PD patients show difficulty in accessing the lexicon related to cognitive impa...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
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