Prognostic impact of microscopic vessel invasion and visceral pleural invasion and their correlations with epithelial –mesenchymal transition, cancer stemness, and treatment failure in lung adenocarcinoma

Visceral pleural invasion (VPI), a pathological invasive finding, has been reported to be a poor prognostic factor in patients with non-small cell lung cancer (NSCLC) [1 –3]. Accordingly, VPI has been incorporated in the current 8th edition of the TNM classification [4,5]. Recent studies have demonstrated that microscopic vessel invasion (MVI), including blood vessel invasion (BVI) and lymphatic vessel invasion (LVI), is a strong independent factor of poor prognos is in patients with NSCLC [6–11].

Source: Lung Cancer - December 7, 2018 Category: Cancer & Oncology Authors: Shinya Neri, Toshi Menju, Terumasa Sowa, Yojiro Yutaka, Daisuke Nakajima, Masatsugu Hamaji, Akihiro Ohsumi, Toyofumi F. Chen-Yoshikawa, Toshihiko Sato, Makoto Sonobe, Akihiko Yoshizawa, Hironori Haga, Hiroshi Date Source Type: research