Maternal high fat diet programs hypothalamic-pituitary-adrenal function in adult rat offspring

Epidemiological and animal studies suggest that, besides the parental heredity and adult lifestyle, the specific environmental factors that a developing offspring experiences in early life may also have a tremendous impact on the development and health problems throughout the life (Barker 2004). Early life challenges such as mother-infant separation and neonatal immune challenge has been reported to increase adult susceptibility to obesity, insulin resistance, hypertension and cardiovascular dysfunction (Gluckman and Hanson 2004; Craft et al., 2006; Warner and Ozanne 2010; Liang et al., 2011).

Source: Psychoneuroendocrinology - December 7, 2018 Category: Psychiatry Authors: XiaoTing Niu, XiaoYun Wu, AnNa Ying, Bei Shao, XiaoFeng Li, WanLi Zhang, ChengCheng Lin, YuanShao Lin Source Type: research