Hypothermic Perfusion of Donor Heart With a Preservation Solution Supplemented by Mesenchymal Stem Cells

Heart transplantation is the definitive treatment for end-stage heart failure. A shortage of donor hearts forced transplant programs to accept older donors and longer ischemic times. Previous studies have suggested that the administration of mesenchymal stem cells (MSCs) or their conditioned medium (CM) protects the heart against ischemia/reperfusion injury (IRI). We hypothesized that the preservation of donor hearts with a CM would protect the graft from IRI after prolonged storage in 15-month-old rats and investigated mRNA-changes attributable to CM.

Source: The Journal of Heart and Lung Transplantation - December 7, 2018 Category: Transplant Surgery Authors: Sevil Korkmaz-Ic öz, Shiliang Li, Regina Hüttner, Mihály Ruppert, Tamás Radovits, Sivakkanan Loganathan, Alex Ali Sayour, Paige Brlecic, Felix Lasitschka, Matthias Karck, Gábor Szabó Tags: Original Pre-Clinical Science Source Type: research