Suppression of metastasis through inhibition of chitinase 3-like 1 expression by miR-125a-3p-mediated up-regulation of USF1

Conclusion: Metastases in mice lung tissues and human lung cancer cell lines were decreased by KD of Chi3L1. USF1 bound to the Chi3L1 promoter, however, Chi3L1 expression was decreased by USF1, despite USF1 enhancing the transcriptional activity of Chi3L1. We found that USF1 induced miR-125a-3p levels which suppressed Chi3L1 expression. Ultimately, our results suggest that lung metastasis is suppressed by knock-down of Chi3L1 through miR-125a-3p-mediated up-regulation of USF1.

Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Ki Cheon Kim, Jaesuk Yun, Dong Ju Son, Ji Young Kim, Jae-Kyung Jung, Jeong Soon Choi, Yu Ri Kim, Ju Kyung Song, Sun Young Kim, Sin Kook Kang, Dae Hwan Shin, Yoon-Seok Roh, Sang-Bae Han, Jin Tae Hong Tags: Research Paper Source Type: research