Radionuclide imaging of VEGFR2 in glioma vasculature using biparatopic affibody conjugate: proof-of-principle in a murine model

Conclusion: The anti-VEGFR2 affibody conjugate [111In]In-NODAGA-ZVEGFR2-Bp2 specifically targeted VEGFR2 in vivo and visualized its expression in a murine GBM orthotopic model. Tumor-to-blood ratios for [111In]In-NODAGA-ZVEGFR2-Bp2 were higher compared to other VEGFR2 imaging probes. [111In]In-NODAGA-ZVEGFR2-Bp2 appears to be a promising probe for in vivo noninvasive visualization of tumor angiogenesis in glioblastoma.

Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Bogdan Mitran, Rezan G ü ler, Francis P. Roche, Elin Lindstr ö m, Ram Kumar Selvaraju, Filippa Fleetwood, Sara S. Rinne, Lena Claesson-Welsh, Vladimir Tolmachev, Stefan St å hl, Anna Orlova, John L ö fblom Tags: Research Paper Source Type: research