Inhibition of Notch1 induces population and suppressive activity of regulatory T cell in inflammatory arthritis

Conclusion: Pharmacological and genetic inhibition of Notch1 signalling suppresses the progression of inflammatory arthritis through modulating the population and suppressive function of Treg cells in animal models of RA.

Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Bo Youn Choi, Yuri Choi, Jong-Sung Park, Li-Jung Kang, Seung Hyun Baek, Jin Su Park, Gahee Bahn, Yoonsuk Cho, Hark Kyun Kim, Jihoon Han, Jae Hoon Sul, Sang-Ha Baik, Dong Hoon Hyun, Thiruma V. Arumugam, Siyoung Yang, Jeung-Whan Han, Young Mo Kang, Yong-Woo Tags: Research Paper Source Type: research