Sonodynamic therapy-induced foam cells apoptosis activates the phagocytic PPAR γ -LXR α -ABCA1/ABCG1 pathway and promotes cholesterol efflux in advanced plaque
Conclusions: Activation of PPARγ-LXRα-ABCA1/ABCG1 pathway induced by ALA-SDT treatment engages a virtuous cycle that enhances efferocytosis, cholesterol efflux and anti-inflammatory reactions in advanced plaque in vivo and in phagocytes in vitro.
Source: Theranostics - Category: Molecular Biology Authors: Huan Wang, Yang Yang, Xin Sun, Fang Tian, Shuyuan Guo, Wei Wang, Zhen Tian, Hong Jin, Zhiguo Zhang, Ye Tian Tags: Research Paper Source Type: research