Sonodynamic therapy-induced foam cells apoptosis activates the phagocytic PPAR γ -LXR α -ABCA1/ABCG1 pathway and promotes cholesterol efflux in advanced plaque

Conclusions: Activation of PPARγ-LXRα-ABCA1/ABCG1 pathway induced by ALA-SDT treatment engages a virtuous cycle that enhances efferocytosis, cholesterol efflux and anti-inflammatory reactions in advanced plaque in vivo and in phagocytes in vitro.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
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