Increased recruitment of endogenous stem cells and chondrogenic differentiation by a composite scaffold containing bone marrow homing peptide for cartilage regeneration

Conclusion: Our findings demonstrated that the composite scaffold could enhance endogenous stem cell homing and chondrogenic differentiation and significantly improve the therapeutic outcome of chondral defects. The present study provides a promising approach for in vivo cartilage repair without cell transplantation. Optimization of this strategy may offer great potential and benefits for clinical application in the future.

Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Jiaju Lu, Xuezhen Shen, Xun Sun, Heyong Yin, Shuhui Yang, Changfeng Lu, Yu Wang, Yifan Liu, Yingqi Huang, Zijin Yang, Xianqi Dong, Chenhao Wang, Quanyi Guo, Lingyun Zhao, Xiaodan Sun, Shibi Lu, Antonios G. Mikos, Jiang Peng, Xiumei Wang Tags: Research Paper Source Type: research