Theranostic pretargeted radioimmunotherapy of internalizing solid tumor antigens in human tumor xenografts in mice: Curative treatment of HER2-positive breast carcinoma

Conclusion: Contrary to popular belief, we demonstrate that DOTA-PRIT can be successfully adapted to an internalizing antigen-antibody system such as HER2, with sufficient TIs and absorbed tumor doses to achieve a high probability of cures of established human breast cancer xenografts while sparing critical organs of significant radiotoxicity.

Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Sarah M. Cheal, Hong Xu, Hong-fen Guo, Mitesh Patel, Blesida Punzalan, Edward K. Fung, Sang-gyu Lee, Meghan Bell, Manisha Singh, Achim A. Jungbluth, Pat B. Zanzonico, Alessandra Piersigilli, Steven M. Larson, Nai-Kong V. Cheung Tags: Research Paper Source Type: research