Targeted imaging and inhibition of triple-negative breast cancer metastases by a PDGFR β aptamer

Conclusions: We propose PDGFRβ as a reliable biomarker of a subgroup of mesenchymal TNBCs with invasive and stem-like phenotype as well as the use of the PDGFRβ aptamer as a high efficacious tool for imaging and suppression of TNBC lung metastases. This study will allow for the significant expansion of the current repertoire of strategies for managing patients with more aggressive TNBC.

Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Simona Camorani, Billy Samuel Hill, Francesca Collina, Sara Gargiulo, Maria Napolitano, Monica Cantile, Maurizio Di Bonito, Gerardo Botti, Monica Fedele, Antonella Zannetti, Laura Cerchia Tags: Research Paper Source Type: research